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Journal of Bacteriology, May 2000, p. 2668-2671, Vol. 182, No. 9
0021-9193/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Equivalence of Lauric Acid and Glycerol Monolaurate as Inhibitors of Signal Transduction in Staphylococcus aureus

Alexey Ruzindagger and Richard P. Novick*

New York University Medical Center, Skirball Institute, New York, New York 10016

Received 8 October 1999/Accepted 7 February 2000

Glycerol monolaurate (GML) inhibits the expression of virulence factors in Staphylococus aureus and the induction of vancomycin resistance in Enterococcus faecalis, presumably by blocking signal transduction. Although GML is rapidly hydrolyzed by bacteria, one of the products, lauric acid, has identical inhibitory activity and is metabolized much more slowly. At least four distinct GML-hydrolyzing activities are identified in S. aureus: the secreted Geh lipase, residual supernatant activity in a geh-null mutant strain, a novel membrane-bound esterase, and a cytoplasmic activity.

* Corresponding author. Mailing address: New York University Medical Center, Skirball Institute, 540 First Ave., New York, NY 10016. Phone: (212) 263-6290. Fax: (212) 263-8951. E-mail: novick{at}saturn.med.nyu.edu.

dagger Present address: Wyeth-Ayerst Research, Pearl River, NY 10965.

Journal of Bacteriology, May 2000, p. 2668-2671, Vol. 182, No. 9
0021-9193/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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