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Journal of Bacteriology, June 2001, p. 3526-3530, Vol. 183, No. 11
0021-9193/01/$04.00+0   DOI: 10.1128/JB.183.11.3526-3530.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

-Ketoacyl Acyl Carrier Protein Synthase III (FabH) Is Essential for Fatty Acid Biosynthesis in Streptomyces coelicolor A3(2)

W. Peter Revill,^* Maureen J. Bibb, Ann-Karolin Scheu, Helen J. Kieser, and David A. Hopwood

John Innes Centre, Norwich Research Park, Colney, Norwich NR4 7UH, United Kingdom

Received 4 December 2000/Accepted 14 March 2001

The Streptomyces coelicolor fab (fatty acid biosynthesis) gene cluster (fabD-fabH-acpP-fabF) is cotranscribed to produce a leaderless mRNA transcript. One of these genes, fabH, encodes a ketoacyl synthase III that is essential to and is proposed to be responsible for initiation of fatty acid biosynthesis in S. coelicolor.

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^* Corresponding author. Present address: Kosan Biosciences, 3832 Bay Center Pl., Hayward, CA 94545. Phone: (510) 732-8400. Fax: (510) 732-8401. E-mail: revill{at}kosan.com.

Present address: C/García Morato no. 14, 28805-Alcalá de Henares, Madrid, Spain.

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Journal of Bacteriology, June 2001, p. 3526-3530, Vol. 183, No. 11
0021-9193/01/$04.00+0   DOI: 10.1128/JB.183.11.3526-3530.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

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