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Journal of Bacteriology, July 2001, p. 4090-4093, Vol. 183, No. 13
0021-9193/01/$04.00+0 DOI: 10.1128/JB.183.13.4090-4093.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.
Efg1, a Morphogenetic Regulator in Candida
albicans, Is a Sequence-Specific DNA Binding Protein
Ping
Leng,
Philip R.
Lee,
Hong
Wu,§ and
Alistair J. P.
Brown*
Department of Molecular and Cell Biology,
University of Aberdeen, Institute of Medical Sciences,
Foresterhill, Aberdeen AB25 2ZD, United Kingdom
Received 2 March 2001/Accepted 10 April 2001
Efg1 is essential for hyphal development in the human pathogen
Candida albicans under most conditions. Efg1 is related to basic helix-loop-helix regulators, and therefore most workers presume
that Efg1 is a transcription factor. Here we confirm that Efg1 is a DNA
binding protein that can interact specifically with the E box.
*
Corresponding author. Mailing address: Department of
Molecular and Cell Biology, University of Aberdeen, Institute of
Medical Sciences, Foresterhill, Aberdeen AB25 2ZD, United Kingdom.
Phone: 44-1224-273183. Fax: 44-1224-273144. E-mail:
al.brown{at}abdn.ac.uk.

Present address: Division of Cellular & Molecular Biology, Ontario
Cancer Institute, University of Toronto, Toronto, Ontario
M5G 2M9,
Canada.

Present address: Laboratory of Developmental Neurobiology, NICHD,
National Institutes of Health, Bethesda, MD 20892-4480.
§
Present address: Eye Research Institute of Canada, University of
Toronto, Toronto, Ontario M5T 2S8,
Canada.
Journal of Bacteriology, July 2001, p. 4090-4093, Vol. 183, No. 13
0021-9193/01/$04.00+0 DOI: 10.1128/JB.183.13.4090-4093.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.
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