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Journal of Bacteriology, July 2001, p. 4090-4093, Vol. 183, No. 13
0021-9193/01/$04.00+0   DOI: 10.1128/JB.183.13.4090-4093.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Efg1, a Morphogenetic Regulator in Candida albicans, Is a Sequence-Specific DNA Binding Protein

Ping Leng,dagger Philip R. Lee,Dagger Hong Wu,§ and Alistair J. P. Brown*

Department of Molecular and Cell Biology, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen AB25 2ZD, United Kingdom

Received 2 March 2001/Accepted 10 April 2001

Efg1 is essential for hyphal development in the human pathogen Candida albicans under most conditions. Efg1 is related to basic helix-loop-helix regulators, and therefore most workers presume that Efg1 is a transcription factor. Here we confirm that Efg1 is a DNA binding protein that can interact specifically with the E box.

* Corresponding author. Mailing address: Department of Molecular and Cell Biology, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen AB25 2ZD, United Kingdom. Phone: 44-1224-273183. Fax: 44-1224-273144. E-mail: al.brown{at}abdn.ac.uk.

dagger Present address: Division of Cellular & Molecular Biology, Ontario Cancer Institute, University of Toronto, Toronto, Ontario M5G 2M9, Canada.

Dagger Present address: Laboratory of Developmental Neurobiology, NICHD, National Institutes of Health, Bethesda, MD 20892-4480.

§ Present address: Eye Research Institute of Canada, University of Toronto, Toronto, Ontario M5T 2S8, Canada.

Journal of Bacteriology, July 2001, p. 4090-4093, Vol. 183, No. 13
0021-9193/01/$04.00+0   DOI: 10.1128/JB.183.13.4090-4093.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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