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Journal of Bacteriology, July 2001, p. 4389-4392, Vol. 183, No. 14
0021-9193/01/$04.00+0   DOI: 10.1128/JB.183.14.4389-4392.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Multiple Genes for the Last Step of Proline Biosynthesis in Bacillus subtilis

Boris R. Belitsky,1,* Jeanette Brill,2 Erhard Bremer,2 and Abraham L. Sonenshein1

Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts 02111,1 and Laboratory for Microbiology, Department of Biology, Philipps University Marburg, D-35032 Marburg, Germany2

Received 20 February 2001/Accepted 25 April 2001

The complete Bacillus subtilis genome contains four genes (proG, proH, proI, and comER) with the potential to encode Delta 1-pyrroline-5-carboxylate reductase, a proline biosynthetic enzyme. Simultaneous defects in three of these genes (proG, proH, and proI) were required to confer proline auxotrophy, indicating that the products of these genes are mostly interchangeable with respect to the last step in proline biosynthesis.

* Corresponding author. Mailing address: Department of Molecular Biology and Microbiology, Tufts University School of Medicine, 136 Harrison Ave., Boston, MA 02111. Phone: (617) 636-6762. Fax: (617) 636-0337. E-mail: address: bbelit02{at}tufts.edu.

Journal of Bacteriology, July 2001, p. 4389-4392, Vol. 183, No. 14
0021-9193/01/$04.00+0   DOI: 10.1128/JB.183.14.4389-4392.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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