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Journal of Bacteriology, August 2001, p. 4905-4909, Vol. 183, No. 16
0021-9193/01/$04.00+0   DOI: 10.1128/JB.183.16.4905-4909.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Control of a Family of Phosphatase Regulatory Genes (phr) by the Alternate Sigma Factor Sigma-H of Bacillus subtilis

Ryan S. McQuade, Natalia Comella, and Alan D. Grossman*

Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139

Received 16 March 2001/Accepted 21 May 2001

A family of 11 phosphatases can help to modulate the activity of response regulator proteins in Bacillus subtilis. Downstream of seven of the rap (phosphatase) genes are phr genes, encoding secreted peptides that function as phosphatase regulators. By using fusions to lacZ and primer extension analysis, we found that six of the seven phr genes are controlled by the alternate sigma factor sigma-H. These results expand the potential of sigma-H to contribute to the output of several response regulators by controlling expression of inhibitors of phosphatases.

* Corresponding author. Mailing address: Department of Biology, Building 68-530, Massachusetts Institute of Technology, Cambridge, MA 02139. Phone: (617) 253-1515. Fax: (617) 253-2643. E-mail: adg{at}mit.edu.

Journal of Bacteriology, August 2001, p. 4905-4909, Vol. 183, No. 16
0021-9193/01/$04.00+0   DOI: 10.1128/JB.183.16.4905-4909.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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