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Journal of Bacteriology, August 2001, p. 4910-4913, Vol. 183, No. 16
0021-9193/01/$04.00+0   DOI: 10.1128/JB.183.16.4910-4913.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

YLR209c Encodes Saccharomyces cerevisiae Purine Nucleoside Phosphorylase

K. Lecoq,1 I. Belloc,2 C. Desgranges,2 M. Konrad,3 and B. Daignan-Fornier1,*

Institut de Biochimie et Génétique Cellulaires, CNRS UMR5095, F-33077 Bordeaux Cedex,1 and INSERM U.441, F-33600 Pessac,2 France, and Department of Molecular Genetics, Max-Planck-Institute for Biophysical Chemistry, D-37070 Göttingen,3 Germany

Received 19 March 2001/Accepted 22 May 2001

The yeast YLR209c (PNP1) gene encodes a protein highly similar to purine nucleoside phosphorylases. This protein specifically metabolized inosine and guanosine. Disruption of PNP1 led to inosine and guanosine excretion in the medium, thus showing that PNP1 plays an important role in the metabolism of these purine nucleosides in vivo.

* Corresponding author. Mailing address: IBGC CNRS UMR5095, 1, rue Camille Saint-Saëns, 33077 Bordeaux Cedex, France. Phone: 33-5-56-99-90-55. Fax: 33-5-56-99-90-59. E-mail: B.Daignan-Fornier{at}ibgc.u-bordeaux2.fr.

Journal of Bacteriology, August 2001, p. 4910-4913, Vol. 183, No. 16
0021-9193/01/$04.00+0   DOI: 10.1128/JB.183.16.4910-4913.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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