JB
Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hoffer, S. M.
Right arrow Articles by Tommassen, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hoffer, S. M.
Right arrow Articles by Tommassen, J.

 Previous Article  |  Next Article 

Journal of Bacteriology, August 2001, p. 4914-4917, Vol. 183, No. 16
0021-9193/01/$04.00+0   DOI: 10.1128/JB.183.16.4914-4917.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Autoamplification of a Two-Component Regulatory System Results in "Learning" Behavior

Sally M. Hoffer,1 Hans V. Westerhoff,2 Klaas J. Hellingwerf,3 Pieter W. Postma,3 and Jan Tommassen1,*

Department of Molecular Microbiology and Institute for Biomembranes, Utrecht University, 3584 CH Utrecht,1 Department of Molecular Cell Physiology, Free University, 1081 HV Amsterdam,2 and Swammerdam Institute for Life Sciences, University of Amsterdam,1018 WS Amsterdam,3 The Netherlands

Received 26 February 2001/Accepted 22 May 2001

We have tested the hypothesis that the autoamplification of two-component regulatory systems results in "learning" behavior, i.e., that bacteria respond faster or more extensively to a signal when a similar signal has been perceived in the past. Indeed, the induction of alkaline phosphatase activity upon phosphate limitation was faster if the cultures had been limited for phosphate previously, and this faster response correlated with the autoamplification of the cognate two-component system.

* Corresponding author. Mailing address: Department of Molecular Microbiology, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands. Phone (31) 30 2532999. Fax (31) 30 2513655. E-mail: J.P.M.Tommassen{at}bio.uu.nl.

Journal of Bacteriology, August 2001, p. 4914-4917, Vol. 183, No. 16
0021-9193/01/$04.00+0   DOI: 10.1128/JB.183.16.4914-4917.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:



Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
Appl. Environ. Microbiol. Infect. Immun. Eukaryot. Cell
Mol. Cell. Biol. J. Virol. Microbiol. Mol. Biol. Rev.
ALL ASM JOURNALS

Copyright © 2001 by the American Society for Microbiology. All rights reserved.