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Journal of Bacteriology, August 2001, p. 4927-4931, Vol. 183, No. 16
0021-9193/01/$04.00+0   DOI: 10.1128/JB.183.16.4927-4931.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

The licC Gene of Streptococcus pneumoniae Encodes a CTP:Phosphocholine Cytidylyltransferase

Charles O. Rock,1,2 Richard J. Heath,1 Hee-Won Park,2,3 and Suzanne Jackowski1,2,*

Protein Science Division, Department of Infectious Diseases,1 and Department of Structural Biology,3 St. Jude Children's Research Hospital, Memphis, Tennessee 38105, and Department of Molecular Biosciences, University of Tennessee Health Science Center, Memphis, Tennessee 381632

Received 12 April 2001/Accepted 23 May 2001

The licC gene product of Streptococcus pneumoniae was expressed and characterized. LicC is a nucleoside triphosphate transferase family member and possesses CTP:phosphocholine cytidylyltransferase activity. Phosphoethanolamine is a poor substrate. The LicC protein plays a role in the biosynthesis of the phosphocholine-derivatized cell wall constituents that are critical for cell separation and pathogenesis.

* Corresponding author. Mailing address: Danny Thomas Research Tower, Rm. 4007B, St. Jude Children's Research Hospital, 332 N. Lauderdale, Memphis, TN 38105-2794. Phone: (901) 495-3494. Fax: (901) 525-8025. E-mail: suzanne.jackowski{at}stjude.org.

Journal of Bacteriology, August 2001, p. 4927-4931, Vol. 183, No. 16
0021-9193/01/$04.00+0   DOI: 10.1128/JB.183.16.4927-4931.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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