This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Yang, M. C.
Right arrow Articles by Losick, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Yang, M. C.
Right arrow Articles by Losick, R.

 Previous Article  |  Next Article 

Journal of Bacteriology, September 2001, p. 5180-5186, Vol. 183, No. 17
0021-9193/01/$04.00+0   DOI: 10.1128/JB.183.17.5180-5186.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Cytological Evidence for Association of the Ends of the Linear Chromosome in Streptomyces coelicolor

Melody C. Yang and Richard Losick*

Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138

Received 5 March 2001/Accepted 4 June 2001

The chromosome of the filamentous bacterium Streptomyces coelicolor is linear, but the genetic map is circular. We present cytological evidence based on the use of fluorescence in situ hybridization showing that the ends of the chromosome frequently colocalize, in agreement with the idea that the ends are held together, effectively forming a circular chromosome. These observations provide a possible explanation for how a linear bacterial chromosome can exhibit a circular genetic map.

* Corresponding author. Mailing address: Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Ave., Cambridge, MA 02138. Phone: (617) 495-4905. Fax: (617) 496-4642. E-mail: losick{at}mcb.harvard.edu.

Journal of Bacteriology, September 2001, p. 5180-5186, Vol. 183, No. 17
0021-9193/01/$04.00+0   DOI: 10.1128/JB.183.17.5180-5186.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Dedrick, R. M., Wildschutte, H., McCormick, J. R. (2009). Genetic Interactions of smc, ftsK, and parB Genes in Streptomyces coelicolor and Their Developmental Genome Segregation Phenotypes. J. Bacteriol. 191: 320-332 [Abstract] [Full Text]  
  • Jyothikumar, V., Tilley, E. J., Wali, R., Herron, P. R. (2008). Time-Lapse Microscopy of Streptomyces coelicolor Growth and Sporulation. Appl. Environ. Microbiol. 74: 6774-6781 [Abstract] [Full Text]  
  • Ventura, M., Canchaya, C., Tauch, A., Chandra, G., Fitzgerald, G. F., Chater, K. F., van Sinderen, D. (2007). Genomics of Actinobacteria: Tracing the Evolutionary History of an Ancient Phylum. Microbiol. Mol. Biol. Rev. 71: 495-548 [Abstract] [Full Text]  
  • Wang, L., Yu, Y., He, X., Zhou, X., Deng, Z., Chater, K. F., Tao, M. (2007). Role of an FtsK-Like Protein in Genetic Stability in Streptomyces coelicolor A3(2). J. Bacteriol. 189: 2310-2318 [Abstract] [Full Text]  
  • Ruban-Osmialowska, B., Jakimowicz, D., Smulczyk-Krawczyszyn, A., Chater, K. F., Zakrzewska-Czerwinska, J. (2006). Replisome Localization in Vegetative and Aerial Hyphae of Streptomyces coelicolor.. J. Bacteriol. 188: 7311-7316 [Abstract] [Full Text]  
  • Smulczyk-Krawczyszyn, A., Jakimowicz, D., Ruban-Osmialowska, B., Zawilak-Pawlik, A., Majka, J., Chater, K., Zakrzewska-Czerwinska, J. (2006). Cluster of DnaA Boxes Involved in Regulation of Streptomyces Chromosome Replication: from In Silico to In Vivo Studies.. J. Bacteriol. 188: 6184-6194 [Abstract] [Full Text]  
  • Jakimowicz, D., Gust, B., Zakrzewska-Czerwinska, J., Chater, K. F. (2005). Developmental-Stage-Specific Assembly of ParB Complexes in Streptomyces coelicolor Hyphae. J. Bacteriol. 187: 3572-3580 [Abstract] [Full Text]  
  • Uchida, T., Ishihara, N., Zenitani, H., Hiratsu, K., Kinashi, H. (2004). Circularized Chromosome with a Large Palindromic Structure in Streptomyces griseus Mutants. J. Bacteriol. 186: 3313-3320 [Abstract] [Full Text]  
  • Kahng, L. S., Shapiro, L. (2003). Polar Localization of Replicon Origins in the Multipartite Genomes of Agrobacterium tumefaciens and Sinorhizobium meliloti. J. Bacteriol. 185: 3384-3391 [Abstract] [Full Text]  
  • Bao, K., Cohen, S. N. (2003). Recruitment of terminal protein to the ends of Streptomyces linear plasmids and chromosomes by a novel telomere-binding protein essential for linear DNA replication. Genes Dev. 17: 774-785 [Abstract] [Full Text]  
  • Uchida, T., Miyawaki, M., Kinashi, H. (2003). Chromosomal Arm Replacement in Streptomyces griseus. J. Bacteriol. 185: 1120-1124 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»