This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sperandio, V.
Right arrow Articles by Kaper, J. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sperandio, V.
Right arrow Articles by Kaper, J. B.

 Previous Article  |  Next Article 

Journal of Bacteriology, September 2001, p. 5187-5197, Vol. 183, No. 17
0021-9193/01/$04.00+0   DOI: 10.1128/JB.183.17.5187-5197.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Quorum Sensing Is a Global Regulatory Mechanism in Enterohemorrhagic Escherichia coli O157:H7

Vanessa Sperandio,1 Alfredo G. Torres,1 Jorge A. Girón,1,2 and James B. Kaper1,*

Center for Vaccine Development and Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland 21201,1 and Centro de Investigaciones in Ciencias Microbiologicas, Instituto de Ciencias, Benemerita Universidad Autonoma de Puebla, Puebla, Mexico2

Received 9 February 2001/Accepted 7 June 2001

Enterohemorrhagic Escherichia coli (EHEC) O157:H7 is responsible for outbreaks of bloody diarrhea and hemolytic-uremic syndrome in many countries. EHEC virulence mechanisms include the production of Shiga toxins (Stx) and formation of attaching and effacing (AE) lesions on intestinal epithelial cells. We recently reported that genes involved in the formation of the AE lesion were regulated by quorum sensing through autoinducer-2, which is synthesized by the product of the luxS gene. In this study we hybridized an E. coli gene array with cDNA synthesized from RNA that was extracted from EHEC strain 86-24 and its isogenic luxS mutant. We observed that 404 genes were regulated by luxS at least fivefold, which comprises approximately 10% of the array genes; 235 of these genes were up-regulated and 169 were down-regulated in the wild-type strain compared to in the luxS mutant. Down-regulated genes included several involved in cell division, as well as ribosomal and tRNA genes. Consistent with this pattern of gene expression, the luxS mutant grows faster than the wild-type strain (generation times of 37.5 and 60 min, respectively, in Dulbecco modified Eagle medium). Up-regulated genes included several involved in the expression and assembly of flagella, motility, and chemotaxis. Using operon::lacZ fusions to class I, II, and III flagellar genes, we were able to confirm this transcriptional regulation. We also observed fewer flagella by Western blotting and electron microscopy and decreased motility halos in semisolid agar in the luxS mutant. The average swimming speeds for the wild-type strain and the luxS mutant are 12.5 and 6.6 µm/s, respectively. We also observed an increase in the production of Stx due to quorum sensing. Genes encoding Stx, which are transcribed along with lambda -like phage genes, are induced by an SOS response, and genes involved in the SOS response were also regulated by quorum sensing. These results indicate that quorum sensing is a global regulatory mechanism for basic physiological functions of E. coli as well as for virulence factors.

* Corresponding author. Mailing address: Center for Vaccine Development, University of Maryland School of Medicine, 685 West Baltimore St., Room 480, Baltimore, MD 21201. Phone: (410) 706-3004. Fax: (410) 706-0182. E-mail: jkaper{at}umaryland.edu.

Journal of Bacteriology, September 2001, p. 5187-5197, Vol. 183, No. 17
0021-9193/01/$04.00+0   DOI: 10.1128/JB.183.17.5187-5197.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Ghosh, D., Roy, K., Williamson, K. E., Srinivasiah, S., Wommack, K. E., Radosevich, M. (2009). Acyl-Homoserine Lactones Can Induce Virus Production in Lysogenic Bacteria: an Alternative Paradigm for Prophage Induction. Appl. Environ. Microbiol. 75: 7142-7152 [Abstract] [Full Text]  
  • Ahmed, N. A., Petersen, F. C., Scheie, A. A. (2009). AI-2/LuxS Is Involved in Increased Biofilm Formation by Streptococcus intermedius in the Presence of Antibiotics. Antimicrob. Agents Chemother. 53: 4258-4263 [Abstract] [Full Text]  
  • Bhatt, S., Edwards, A. N., Nguyen, H. T. T., Merlin, D., Romeo, T., Kalman, D. (2009). The RNA Binding Protein CsrA Is a Pleiotropic Regulator of the Locus of Enterocyte Effacement Pathogenicity Island of Enteropathogenic Escherichia coli. Infect. Immun. 77: 3552-3568 [Abstract] [Full Text]  
  • Yang, Z., Kim, J., Zhang, C., Zhang, M., Nietfeldt, J., Southward, C. M., Surette, M. G., Kachman, S. D., Benson, A. K. (2009). Genomic Instability in Regions Adjacent to a Highly Conserved pch Prophage in Escherichia coli O157:H7 Generates Diversity in Expression Patterns of the LEE Pathogenicity Island. J. Bacteriol. 191: 3553-3568 [Abstract] [Full Text]  
  • Price, N. L., Raivio, T. L. (2009). Characterization of the Cpx Regulon in Escherichia coli Strain MC4100. J. Bacteriol. 191: 1798-1815 [Abstract] [Full Text]  
  • Medellin-Pena, M. J., Griffiths, M. W. (2009). Effect of Molecules Secreted by Lactobacillus acidophilus Strain La-5 on Escherichia coli O157:H7 Colonization. Appl. Environ. Microbiol. 75: 1165-1172 [Abstract] [Full Text]  
  • Hirakawa, H., Kodama, T., Takumi-Kobayashi, A., Honda, T., Yamaguchi, A. (2009). Secreted indole serves as a signal for expression of type III secretion system translocators in enterohaemorrhagic Escherichia coli O157 : H7. Microbiology 155: 541-550 [Abstract] [Full Text]  
  • de Sablet, T., Chassard, C., Bernalier-Donadille, A., Vareille, M., Gobert, A. P., Martin, C. (2009). Human Microbiota-Secreted Factors Inhibit Shiga Toxin Synthesis by Enterohemorrhagic Escherichia coli O157:H7. Infect. Immun. 77: 783-790 [Abstract] [Full Text]  
  • Quinones, B., Miller, W. G., Bates, A. H., Mandrell, R. E. (2009). Autoinducer-2 Production in Campylobacter jejuni Contributes to Chicken Colonization. Appl. Environ. Microbiol. 75: 281-285 [Abstract] [Full Text]  
  • Mellies, J. L., Larabee, F. J., Zarr, M. A., Horback, K. L., Lorenzen, E., Mavor, D. (2008). Ler interdomain linker is essential for anti-silencing activity in enteropathogenic Escherichia coli. Microbiology 154: 3624-3638 [Abstract] [Full Text]  
  • Fujii, T., Ingham, C., Nakayama, J., Beerthuyzen, M., Kunuki, R., Molenaar, D., Sturme, M., Vaughan, E., Kleerebezem, M., de Vos, W. (2008). Two Homologous Agr-Like Quorum-Sensing Systems Cooperatively Control Adherence, Cell Morphology, and Cell Viability Properties in Lactobacillus plantarum WCFS1. J. Bacteriol. 190: 7655-7665 [Abstract] [Full Text]  
  • Jelcic, I., Hufner, E., Schmidt, H., Hertel, C. (2008). Repression of the Locus of the Enterocyte Effacement-Encoded Regulator of Gene Transcription of Escherichia coli O157:H7 by Lactobacillus reuteri Culture Supernatants Is LuxS and Strain Dependent. Appl. Environ. Microbiol. 74: 3310-3314 [Abstract] [Full Text]  
  • Hoang, H. H., Gurich, N., Gonzalez, J. E. (2008). Regulation of Motility by the ExpR/Sin Quorum-Sensing System in Sinorhizobium meliloti. J. Bacteriol. 190: 861-871 [Abstract] [Full Text]  
  • Karavolos, M. H., Bulmer, D. M., Winzer, K., Wilson, M., Mastroeni, P., Williams, P., Khan, C. M. A. (2008). LuxS Affects Flagellar Phase Variation Independently of Quorum Sensing in Salmonella enterica Serovar Typhimurium. J. Bacteriol. 190: 769-771 [Abstract] [Full Text]  
  • Sztajer, H., Lemme, A., Vilchez, R., Schulz, S., Geffers, R., Yip, C. Y. Y., Levesque, C. M., Cvitkovitch, D. G., Wagner-Dobler, I. (2008). Autoinducer-2-Regulated Genes in Streptococcus mutans UA159 and Global Metabolic Effect of the luxS Mutation. J. Bacteriol. 190: 401-415 [Abstract] [Full Text]  
  • Choi, J., Shin, D., Ryu, S. (2007). Implication of Quorum Sensing in Salmonella enterica Serovar Typhimurium Virulence: the luxS Gene Is Necessary for Expression of Genes in Pathogenicity Island 1. Infect. Immun. 75: 4885-4890 [Abstract] [Full Text]  
  • Kendall, M. M., Rasko, D. A., Sperandio, V. (2007). Global Effects of the Cell-to-Cell Signaling Molecules Autoinducer-2, Autoinducer-3, and Epinephrine in a luxS Mutant of Enterohemorrhagic Escherichia coli. Infect. Immun. 75: 4875-4884 [Abstract] [Full Text]  
  • Mellies, J. L., Barron, A. M. S., Carmona, A. M. (2007). Enteropathogenic and Enterohemorrhagic Escherichia coli Virulence Gene Regulation. Infect. Immun. 75: 4199-4210 [Full Text]  
  • Bansal, T., Englert, D., Lee, J., Hegde, M., Wood, T. K., Jayaraman, A. (2007). Differential Effects of Epinephrine, Norepinephrine, and Indole on Escherichia coli O157:H7 Chemotaxis, Colonization, and Gene Expression. Infect. Immun. 75: 4597-4607 [Abstract] [Full Text]  
  • Shao, H., Lamont, R. J., Demuth, D. R. (2007). Autoinducer 2 Is Required for Biofilm Growth of Aggregatibacter (Actinobacillus) actinomycetemcomitans. Infect. Immun. 75: 4211-4218 [Abstract] [Full Text]  
  • Shao, H., James, D., Lamont, R. J., Demuth, D. R. (2007). Differential Interaction of Aggregatibacter (Actinobacillus) actinomycetemcomitans LsrB and RbsB Proteins with Autoinducer 2. J. Bacteriol. 189: 5559-5565 [Abstract] [Full Text]  
  • Williams, P., Winzer, K., Chan, W. C, Camara, M. (2007). Look who's talking: communication and quorum sensing in the bacterial world. Phil Trans R Soc B 362: 1119-1134 [Abstract] [Full Text]  
  • Barnard, A. M.L, Bowden, S. D, Burr, T., Coulthurst, S. J, Monson, R. E, Salmond, G. P.C (2007). Quorum sensing, virulence and secondary metabolite production in plant soft-rotting bacteria. Phil Trans R Soc B 362: 1165-1183 [Abstract] [Full Text]  
  • Russell, R. M., Sharp, F. C., Rasko, D. A., Sperandio, V. (2007). QseA and GrlR/GrlA Regulation of the Locus of Enterocyte Effacement Genes in Enterohemorrhagic Escherichia coli. J. Bacteriol. 189: 5387-5392 [Abstract] [Full Text]  
  • Ahmed, N. A. A. M., Petersen, F. C., Scheie, A. A. (2007). AI-2 quorum sensing affects antibiotic susceptibility in Streptococcus anginosus. J Antimicrob Chemother 60: 49-53 [Abstract] [Full Text]  
  • Medellin-Pena, M. J., Wang, H., Johnson, R., Anand, S., Griffiths, M. W. (2007). Probiotics Affect Virulence-Related Gene Expression in Escherichia coli O157:H7. Appl. Environ. Microbiol. 73: 4259-4267 [Abstract] [Full Text]  
  • Reading, N. C., Torres, A. G., Kendall, M. M., Hughes, D. T., Yamamoto, K., Sperandio, V. (2007). A Novel Two-Component Signaling System That Activates Transcription of an Enterohemorrhagic Escherichia coli Effector Involved in Remodeling of Host Actin. J. Bacteriol. 189: 2468-2476 [Abstract] [Full Text]  
  • Gonzalez, J. E., Keshavan, N. D. (2006). Messing with Bacterial Quorum Sensing. Microbiol. Mol. Biol. Rev. 70: 859-875 [Abstract] [Full Text]  
  • Hilton, T., Rosche, T., Froelich, B., Smith, B., Oliver, J. (2006). Capsular Polysaccharide Phase Variation in Vibrio vulnificus. Appl. Environ. Microbiol. 72: 6986-6993 [Abstract] [Full Text]  
  • Krin, E., Chakroun, N., Turlin, E., Givaudan, A., Gaboriau, F., Bonne, I., Rousselle, J.-C., Frangeul, L., Lacroix, C., Hullo, M.-F., Marisa, L., Danchin, A., Derzelle, S. (2006). Pleiotropic Role of Quorum-Sensing Autoinducer 2 in Photorhabdus luminescens.. Appl. Environ. Microbiol. 72: 6439-6451 [Abstract] [Full Text]  
  • Walters, M., Sperandio, V. (2006). Autoinducer 3 and Epinephrine Signaling in the Kinetics of Locus of Enterocyte Effacement Gene Expression in Enterohemorrhagic Escherichia coli.. Infect. Immun. 74: 5445-5455 [Abstract] [Full Text]  
  • Motegi, M., Takagi, Y., Yonezawa, H., Hanada, N., Terajima, J., Watanabe, H., Senpuku, H. (2006). Assessment of Genes Associated with Streptococcus mutans Biofilm Morphology. Appl. Environ. Microbiol. 72: 6277-6287 [Abstract] [Full Text]  
  • Walters, M., Sircili, M. P., Sperandio, V. (2006). AI-3 Synthesis Is Not Dependent on luxS in Escherichia coli.. J. Bacteriol. 188: 5668-5681 [Abstract] [Full Text]  
  • Clarke, M. B., Hughes, D. T., Zhu, C., Boedeker, E. C., Sperandio, V. (2006). The QseC sensor kinase: A bacterial adrenergic receptor. Proc. Natl. Acad. Sci. USA 103: 10420-10425 [Abstract] [Full Text]  
  • James, C. E., Hasegawa, Y., Park, Y., Yeung, V., Tribble, G. D., Kuboniwa, M., Demuth, D. R., Lamont, R. J. (2006). LuxS Involvement in the Regulation of Genes Coding for Hemin and Iron Acquisition Systems in Porphyromonas gingivalis. Infect. Immun. 74: 3834-3844 [Abstract] [Full Text]  
  • James, D., Shao, H., Lamont, R. J., Demuth, D. R. (2006). The Actinobacillus actinomycetemcomitans Ribose Binding Protein RbsB Interacts with Cognate and Heterologous Autoinducer 2 Signals. Infect. Immun. 74: 4021-4029 [Abstract] [Full Text]  
  • Pruss, B. M., Besemann, C., Denton, A., Wolfe, A. J. (2006). A Complex Transcription Network Controls the Early Stages of Biofilm Development by Escherichia coli. J. Bacteriol. 188: 3731-3739 [Full Text]  
  • Lievin-Le Moal, V., Servin, A. L. (2006). The Front Line of Enteric Host Defense against Unwelcome Intrusion of Harmful Microorganisms: Mucins, Antimicrobial Peptides, and Microbiota. Clin. Microbiol. Rev. 19: 315-337 [Abstract] [Full Text]  
  • Domka, J., Lee, J., Wood, T. K. (2006). YliH (BssR) and YceP (BssS) Regulate Escherichia coli K-12 Biofilm Formation by Influencing Cell Signaling. Appl. Environ. Microbiol. 72: 2449-2459 [Abstract] [Full Text]  
  • Challan Belval, S., Gal, L., Margiewes, S., Garmyn, D., Piveteau, P., Guzzo, J. (2006). Assessment of the Roles of LuxS, S-Ribosyl Homocysteine, and Autoinducer 2 in Cell Attachment during Biofilm Formation by Listeria monocytogenes EGD-e. Appl. Environ. Microbiol. 72: 2644-2650 [Abstract] [Full Text]  
  • Low, A. S., Dziva, F., Torres, A. G., Martinez, J. L., Rosser, T., Naylor, S., Spears, K., Holden, N., Mahajan, A., Findlay, J., Sales, J., Smith, D. G. E., Low, J. C., Stevens, M. P., Gally, D. L. (2006). Cloning, Expression, and Characterization of Fimbrial Operon F9 from Enterohemorrhagic Escherichia coli O157:H7. Infect. Immun. 74: 2233-2244 [Abstract] [Full Text]  
  • Doherty, N., Holden, M. T. G., Qazi, S. N., Williams, P., Winzer, K. (2006). Functional Analysis of luxS in Staphylococcus aureus Reveals a Role in Metabolism but Not Quorum Sensing.. J. Bacteriol. 188: 2885-2897 [Abstract] [Full Text]  
  • Yang, S., Lopez, C. R., Zechiedrich, E. L. (2006). Quorum sensing and multidrug transporters in Escherichia coli. Proc. Natl. Acad. Sci. USA 103: 2386-2391 [Abstract] [Full Text]  
  • Herzberg, M., Kaye, I. K., Peti, W., Wood, T. K. (2006). YdgG (TqsA) Controls Biofilm Formation in Escherichia coli K-12 through Autoinducer 2 Transport. J. Bacteriol. 188: 587-598 [Abstract] [Full Text]  
  • Xu, L., Li, H., Vuong, C., Vadyvaloo, V., Wang, J., Yao, Y., Otto, M., Gao, Q. (2006). Role of the luxS Quorum-Sensing System in Biofilm Formation and Virulence of Staphylococcus epidermidis. Infect. Immun. 74: 488-496 [Abstract] [Full Text]  
  • Gonzalez Barrios, A. F., Zuo, R., Hashimoto, Y., Yang, L., Bentley, W. E., Wood, T. K. (2006). Autoinducer 2 Controls Biofilm Formation in Escherichia coli through a Novel Motility Quorum-Sensing Regulator (MqsR, B3022). J. Bacteriol. 188: 305-316 [Abstract] [Full Text]  
  • Wang, L., Li, J., March, J. C., Valdes, J. J., Bentley, W. E. (2005). luxS-Dependent Gene Regulation in Escherichia coli K-12 Revealed by Genomic Expression Profiling. J. Bacteriol. 187: 8350-8360 [Abstract] [Full Text]  
  • Ren, D., Zuo, R., Gonzalez Barrios, A. F., Bedzyk, L. A., Eldridge, G. R., Pasmore, M. E., Wood, T. K. (2005). Differential Gene Expression for Investigation of Escherichia coli Biofilm Inhibition by Plant Extract Ursolic Acid. Appl. Environ. Microbiol. 71: 4022-4034 [Abstract] [Full Text]  
  • Yuan, L., Hillman, J. D., Progulske-Fox, A. (2005). Microarray Analysis of Quorum-Sensing-Regulated Genes in Porphyromonas gingivalis. Infect. Immun. 73: 4146-4154 [Abstract] [Full Text]  
  • Kaper, J. B., Sperandio, V. (2005). Bacterial Cell-to-Cell Signaling in the Gastrointestinal Tract. Infect. Immun. 73: 3197-3209 [Full Text]  
  • Clarke, M. B., Sperandio, V. (2005). Events at the Host-Microbial Interface of the Gastrointestinal Tract III. Cell-to-cell signaling among microbial flora, host, and pathogens: there is a whole lot of talking going on. Am. J. Physiol. Gastrointest. Liver Physiol. 288: G1105-G1109 [Abstract] [Full Text]  
  • Babb, K., von Lackum, K., Wattier, R. L., Riley, S. P., Stevenson, B. (2005). Synthesis of Autoinducer 2 by the Lyme Disease Spirochete, Borrelia burgdorferi. J. Bacteriol. 187: 3079-3087 [Abstract] [Full Text]  
  • Servin, A. L. (2005). Pathogenesis of Afa/Dr Diffusely Adhering Escherichia coli. Clin. Microbiol. Rev. 18: 264-292 [Abstract] [Full Text]  
  • Wang, L., Hashimoto, Y., Tsao, C.-Y., Valdes, J. J., Bentley, W. E. (2005). Cyclic AMP (cAMP) and cAMP Receptor Protein Influence both Synthesis and Uptake of Extracellular Autoinducer 2 in Escherichia coli. J. Bacteriol. 187: 2066-2076 [Abstract] [Full Text]  
  • Herold, S., Siebert, J., Huber, A., Schmidt, H. (2005). Global Expression of Prophage Genes in Escherichia coli O157:H7 Strain EDL933 in Response to Norfloxacin. Antimicrob. Agents Chemother. 49: 931-944 [Abstract] [Full Text]  
  • Jordan, D. M., Sperandio, V., Kaper, J. B., Dean-Nystrom, E. A., Moon, H. W. (2005). Colonization of Gnotobiotic Piglets by a luxS Mutant Strain of Escherichia coli O157:H7. Infect. Immun. 73: 1214-1216 [Abstract] [Full Text]  
  • Xavier, K. B., Bassler, B. L. (2005). Regulation of Uptake and Processing of the Quorum-Sensing Autoinducer AI-2 in Escherichia coli. J. Bacteriol. 187: 238-248 [Abstract] [Full Text]  
  • Schauder, S., Penna, L., Ritton, A., Manin, C., Parker, F., Renauld-Mongenie, G. (2005). Proteomics Analysis by Two-Dimensional Differential Gel Electrophoresis Reveals the Lack of a Broad Response of Neisseria meningitidis to In Vitro-Produced AI-2. J. Bacteriol. 187: 392-395 [Abstract] [Full Text]  
  • Sturgill, G., Toutain, C. M., Komperda, J., O'Toole, G. A., Rather, P. N. (2004). Role of CysE in Production of an Extracellular Signaling Molecule in Providencia stuartii and Escherichia coli: Loss of cysE Enhances Biofilm Formation in Escherichia coli. J. Bacteriol. 186: 7610-7617 [Abstract] [Full Text]  
  • Loh, J. T., Forsyth, M. H., Cover, T. L. (2004). Growth Phase Regulation of flaA Expression in Helicobacter pylori Is luxS Dependent. Infect. Immun. 72: 5506-5510 [Abstract] [Full Text]  
  • Ren, D., Bedzyk, L. A., Setlow, P., England, D. F., Kjelleberg, S., Thomas, S. M., Ye, R. W., Wood, T. K. (2004). Differential Gene Expression To Investigate the Effect of (5Z)-4-Bromo- 5-(Bromomethylene)-3-Butyl-2(5H)-Furanone on Bacillus subtilis. Appl. Environ. Microbiol. 70: 4941-4949 [Abstract] [Full Text]  
  • Denkin, S. M., Nelson, D. R. (2004). Regulation of Vibrio anguillarum empA Metalloprotease Expression and Its Role in Virulence. Appl. Environ. Microbiol. 70: 4193-4204 [Abstract] [Full Text]  
  • Lux, R., Shi, W. (2004). CHEMOTAXIS-GUIDED MOVEMENTS IN BACTERIA. CROBM 15: 207-220 [Abstract] [Full Text]  
  • Winans, S. C. (2004). Reciprocal Regulation of Bioluminescence and Type III Protein Secretion in Vibrio harveyi and Vibrio parahaemolyticus in Response to Diffusible Chemical Signals. J. Bacteriol. 186: 3674-3676 [Full Text]  
  • Ihssen, J., Egli, T. (2004). Specific growth rate and not cell density controls the general stress response in Escherichia coli. Microbiology 150: 1637-1648 [Abstract] [Full Text]  
  • Coulthurst, S. J., Kurz, C. L., Salmond, G. P. C. (2004). luxS mutants of Serratia defective in autoinducer-2-dependent 'quorum sensing' show strain-dependent impacts on virulence and production of carbapenem and prodigiosin. Microbiology 150: 1901-1910 [Abstract] [Full Text]  
  • Joyce, E. A., Kawale, A., Censini, S., Kim, C. C., Covacci, A., Falkow, S. (2004). LuxS Is Required for Persistent Pneumococcal Carriage and Expression of Virulence and Biosynthesis Genes. Infect. Immun. 72: 2964-2975 [Abstract] [Full Text]  
  • Ren, D., Bedzyk, L. A., Ye, R. W., Thomas, S. M., Wood, T. K. (2004). Stationary-Phase Quorum-Sensing Signals Affect Autoinducer-2 and Gene Expression in Escherichia coli. Appl. Environ. Microbiol. 70: 2038-2043 [Abstract] [Full Text]  
  • Sircili, M. P., Walters, M., Trabulsi, L. R., Sperandio, V. (2004). Modulation of Enteropathogenic Escherichia coli Virulence by Quorum Sensing. Infect. Immun. 72: 2329-2337 [Abstract] [Full Text]  
  • Brombacher, E., Dorel, C., Zehnder, A. J. B., Landini, P. (2003). The curli biosynthesis regulator CsgD co-ordinates the expression of both positive and negative determinants for biofilm formation in Escherichia coli. Microbiology 149: 2847-2857 [Abstract] [Full Text]  
  • Blehert, D. S., Palmer, R. J. Jr., Xavier, J. B., Almeida, J. S., Kolenbrander, P. E. (2003). Autoinducer 2 Production by Streptococcus gordonii DL1 and the Biofilm Phenotype of a luxS Mutant Are Influenced by Nutritional Conditions. J. Bacteriol. 185: 4851-4860 [Abstract] [Full Text]  
  • Cooley, M. B., Miller, W. G., Mandrell, R. E. (2003). Colonization of Arabidopsis thaliana with Salmonella enterica and Enterohemorrhagic Escherichia coli O157:H7 and Competition by Enterobacter asburiae. Appl. Environ. Microbiol. 69: 4915-4926 [Abstract] [Full Text]  
  • Sperandio, V., Torres, A. G., Jarvis, B., Nataro, J. P., Kaper, J. B. (2003). Bacteria-host communication: The language of hormones. Proc. Natl. Acad. Sci. USA 100: 8951-8956 [Abstract] [Full Text]  
  • Dove, J. E., Yasukawa, K., Tinsley, C. R., Nassif, X. (2003). Production of the signalling molecule, autoinducer-2, by Neisseria meningitidis: lack of evidence for a concerted transcriptional response. Microbiology 149: 1859-1869 [Abstract] [Full Text]  
  • McNab, R., Lamont, R. J. (2003). Microbial dinner-party conversations: the role of LuxS in interspecies communication. J Med Microbiol 52: 541-545 [Abstract] [Full Text]  
  • Nishino, K., Inazumi, Y., Yamaguchi, A. (2003). Global Analysis of Genes Regulated by EvgA of the Two-Component Regulatory System in Escherichia coli. J. Bacteriol. 185: 2667-2672 [Abstract] [Full Text]  
  • Fong, K. P., Gao, L., Demuth, D. R. (2003). luxS and arcB Control Aerobic Growth of Actinobacillus actinomycetemcomitans under Iron Limitation. Infect. Immun. 71: 298-308 [Abstract] [Full Text]  
  • McNab, R., Ford, S. K., El-Sabaeny, A., Barbieri, B., Cook, G. S., Lamont, R. J. (2003). LuxS-Based Signaling in Streptococcus gordonii: Autoinducer 2 Controls Carbohydrate Metabolism and Biofilm Formation with Porphyromonas gingivalis. J. Bacteriol. 185: 274-284 [Abstract] [Full Text]  
  • Stevenson, B., Babb, K. (2002). LuxS-Mediated Quorum Sensing in Borrelia burgdorferi, the Lyme Disease Spirochete. Infect. Immun. 70: 4099-4105 [Abstract] [Full Text]  
  • Beeston, A. L., Surette, M. G. (2002). pfs-Dependent Regulation of Autoinducer 2 Production in Salmonella enterica Serovar Typhimurium. J. Bacteriol. 184: 3450-3456 [Abstract] [Full Text]  
  • Sperandio, V., Li, C. C., Kaper, J. B. (2002). Quorum-Sensing Escherichia coli Regulator A: a Regulator of the LysR Family Involved in the Regulation of the Locus of Enterocyte Effacement Pathogenicity Island in Enterohemorrhagic E. coli. Infect. Immun. 70: 3085-3093 [Abstract] [Full Text]  
  • Elvers, K. T., Park, S. F. (2002). Quorum sensing in Campylobacter jejuni: detection of a luxS encoded signalling molecule. Microbiology 148: 1475-1481 [Abstract] [Full Text]  
  • Winzer, K., Hardie, K. R., Burgess, N., Doherty, N., Kirke, D., Holden, M. T. G., Linforth, R., Cornell, K. A., Taylor, A. J., Hill, P. J., Williams, P. (2002). LuxS: its role in central metabolism and the in vitro synthesis of 4-hydroxy-5-methyl-3(2H)-furanone. Microbiology 148: 909-922 [Abstract] [Full Text]  
  • Revel, A. T., Talaat, A. M., Norgard, M. V. (2002). DNA microarray analysis of differential gene expression in Borrelia burgdorferi, the Lyme disease spirochete. Proc. Natl. Acad. Sci. USA 99: 1562-1567 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»