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Journal of Bacteriology, September 2001, p. 5449-5452, Vol. 183, No. 18
0021-9193/01/$04.00+0   DOI: 10.1128/JB.183.18.5449-5452.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Polymer Stability Plays an Important Role in the Positional Regulation of FtsZ

Petra Anne Levin,1,* Rachel L. Schwartz,1 and Alan D. Grossman2

Department of Biology, Washington University, St. Louis, Missouri 63130,1 and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 021392

Received 27 April 2001/Accepted 25 June 2001

We conducted a series of experiments examining the effect of polymer stability on FtsZ localization dynamics in Bacillus subtilis. A loss-of-function mutation in ezrA, a putative polymer-destabilizing factor, suppresses the defects in FtsZ polymer stability associated with minCD overexpression. In addition, a mutation that is predicted to stabilize the FtsZ polymer leads to the formation of polar FtsZ rings. These data support the hypothesis that carefully balanced polymer stability is important for the assembly and localization of FtsZ during the bacterial cell cycle.

* Corresponding author. Mailing address: Department of Biology, Washington University, Campus Box 1137, One Brookings Drive, St. Louis, MO 63130. Phone: (314) 935-7888. Fax: (314) 935-4432. E-mail: plevin{at}biology.wustl.edu.

Journal of Bacteriology, September 2001, p. 5449-5452, Vol. 183, No. 18
0021-9193/01/$04.00+0   DOI: 10.1128/JB.183.18.5449-5452.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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