Complete Nucleotide Sequence of a 43-Kilobase Genomic Island Associated with the Multidrug Resistance Region of Salmonella enterica Serovar Typhimurium DT104 and Its Identification in Phage Type DT120 and Serovar Agona

doi:10.1128/JB.183.19.5725-5732.2001

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Journal of Bacteriology, October 2001, p. 5725-5732, Vol. 183, No. 19
0021-9193/01/$04.00+0 DOI: 10.1128/JB.183.19.5725-5732.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Complete Nucleotide Sequence of a 43-Kilobase Genomic Island Associated with the Multidrug Resistance Region of Salmonella enterica Serovar Typhimurium DT104 and Its Identification in Phage Type DT120 and Serovar Agona

David Boyd,¹ Geoffrey A. Peters,¹ Axel Cloeckaert,² Karim Sidi Boumedine,² Elisabeth Chaslus-Dancla,² Hein Imberechts,³ and Michael R. Mulvey¹^,^*

National Microbiology Laboratory, Health Canada, Winnipeg, Manitoba R3E 3R2, Canada¹; Station de Pathologie Aviaire et Parasitologie, Institut National de la Recherche Agronomique, 37380 Nouzilly, France²; and Centre d'Etude et de Recherches Vétérinaires et Agrochimiques, B-1180 Brussels, Belgium³

Received 14 February 2001/Accepted 5 July 2001

This study describes the characterization of the recently described Salmonella genomic island 1 (SGI1) (D. A. Boyd, G. A.Peters, L.-K. Ng, and M. R. Mulvey, FEMS Microbiol. Lett. 189:285-291,2000), which harbors the genes associated with the ACSSuT phenotypein a Canadian isolate of Salmonella enterica serovar TyphimuriumDT104. A 43-kb region has been completely sequenced and foundto contain 44 predicted open reading frames (ORFs) which comprised~87% of the total sequence. Fifteen ORFs did not show any significanthomology to known gene sequences. A number of ORFs show significanthomology to plasmid-related genes, suggesting, at least in part,a plasmid origin for the SGI1, although some with homology tophage-related genes were identified. The SGI1 was identified ina number of multidrug-resistant DT120 and S. enterica serovarAgona strains with similar antibiotic-resistant phenotypes. TheG+C content suggests a potential mosaic structure for the SGI1.Emergence of the SGI1 in serovar Agona strains isdiscussed.

^* Corresponding author. Mailing address: Nosocomial Infections, National Microbiology Laboratory, Health Canada, 1015 ArlingtonSt., Winnipeg, Manitoba, Canada R3E 3R2. Phone: (204) 789-2133.Fax: (204) 789-2018. E-mail: Michael_Mulvey{at}hc-sc.gc.ca.

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