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Journal of Bacteriology, October 2001, p. 5725-5732, Vol. 183, No. 19
National Microbiology Laboratory, Health
Canada, Winnipeg, Manitoba R3E 3R2, Canada1;
Station de Pathologie Aviaire et Parasitologie, Institut
National de la Recherche Agronomique, 37380 Nouzilly,
France2; and Centre d'Etude et de
Recherches Vétérinaires et Agrochimiques, B-1180 Brussels,
Belgium3
Received 14 February 2001/Accepted 5 July 2001
This study describes the characterization of the recently described
Salmonella genomic island 1 (SGI1) (D. A. Boyd,
G. A. Peters, L.-K. Ng, and M. R. Mulvey, FEMS Microbiol.
Lett. 189:285-291, 2000), which harbors the genes associated with the
ACSSuT phenotype in a Canadian isolate of Salmonella
enterica serovar Typhimurium DT104. A 43-kb region has been
completely sequenced and found to contain 44 predicted open reading
frames (ORFs) which comprised ~87% of the total sequence. Fifteen
ORFs did not show any significant homology to known gene sequences. A
number of ORFs show significant homology to plasmid-related genes,
suggesting, at least in part, a plasmid origin for the SGI1, although
some with homology to phage-related genes were identified. The SGI1 was
identified in a number of multidrug-resistant DT120 and S. enterica serovar Agona strains with similar antibiotic-resistant
phenotypes. The G+C content suggests a potential mosaic structure for
the SGI1. Emergence of the SGI1 in serovar Agona strains is discussed.
0021-9193/01/$04.00+0 DOI: 10.1128/JB.183.19.5725-5732.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.
Complete Nucleotide Sequence of a 43-Kilobase Genomic Island
Associated with the Multidrug Resistance Region of Salmonella
enterica Serovar Typhimurium DT104 and Its Identification in
Phage Type DT120 and Serovar Agona
*
Corresponding author. Mailing address: Nosocomial
Infections, National Microbiology Laboratory, Health Canada, 1015 Arlington St., Winnipeg, Manitoba, Canada R3E 3R2. Phone: (204)
789-2133. Fax: (204) 789-2018. E-mail:
Michael_Mulvey{at}hc-sc.gc.ca.
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