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Journal of Bacteriology, October 2001, p. 5747-5750, Vol. 183, No. 19
0021-9193/01/$04.00+0   DOI: 10.1128/JB.183.19.5747-5750.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

The djlA Gene Acts Synergistically with dnaJ in Promoting Escherichia coli Growth

Pierre Genevaux,* Françoise Schwager, Costa Georgopoulos, and William L. Kelley

Département de Biochimie Médicale, Centre Médical Universitaire, Université de Genève, 1211 Genève 4, Switzerland

Received 11 April 2001/Accepted 11 July 2001

The DnaK chaperone of Escherichia coli is known to interact with the J domains of DnaJ, CbpA, and DjlA. By constructing multiple mutants, we found that the djlA gene was essential for bacterial growth above 37°C in the absence of dnaJ. This essentiality depended upon the J domain of DjlA but not upon the normal membrane location of DjlA.

* Corresponding author. Mailing address: Département de Biochimie Médicale, Centre Médical Universitaire, Université de Genève, 1, rue Michel-Servet, 1211 Genève 4, Switzerland. Phone: (41) 22 702 55 14. Fax: (41) 22 702 55 02. E-mail: pierre.genevaux{at}medecine.unige.ch.

Journal of Bacteriology, October 2001, p. 5747-5750, Vol. 183, No. 19
0021-9193/01/$04.00+0   DOI: 10.1128/JB.183.19.5747-5750.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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