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Journal of Bacteriology, December 2001, p. 6733-6739, Vol. 183, No. 23
0021-9193/01/$04.00+0 DOI: 10.1128/JB.183.23.6733-6739.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.
Analyses of mrp Genes during Myxococcus
xanthus Development
Hong
Sun and
Wenyuan
Shi*
Molecular Biology Institute and School of
Dentistry, University of California, Los Angeles, California 90095-1668
Received 26 April 2001/Accepted 31 August 2001
Myxococcus xanthus is a gram-negative soil bacterium
that undergoes development under starvation conditions. Our previous study identified a new genetic locus, mrp, which is
required for both fruiting body formation and sporulation. The locus
encodes two transcripts: mrpAB, which consists of a
histidine kinase and an NtrC-like response regulator, and
mrpC, a cyclic AMP receptor protein family
transcription activator. In this study, we used genetic and biochemical
analyses to investigate the possible interactions between the
mrp genes and other known developmental genes and events. These studies show that the mrp genes possibly
function after A-signaling and (p)ppGpp but before C-signaling and that they regulate various early and late developmental genes and events.
*
Corresponding author. Mailing address: UCLA Molecular
Biology Institute and School of Dentistry, P.O. Box 951668, 10833 Le Conte Avenue, Los Angeles, CA 90095-1668. Phone: (310) 825-8356. Fax:
(310) 794-7109. E-mail: wenyuan{at}ucla.edu.
Journal of Bacteriology, December 2001, p. 6733-6739, Vol. 183, No. 23
0021-9193/01/$04.00+0 DOI: 10.1128/JB.183.23.6733-6739.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.
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