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Journal of Bacteriology, December 2001, p. 6733-6739, Vol. 183, No. 23
0021-9193/01/$04.00+0   DOI: 10.1128/JB.183.23.6733-6739.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Analyses of mrp Genes during Myxococcus xanthus Development

Hong Sun and Wenyuan Shi*

Molecular Biology Institute and School of Dentistry, University of California, Los Angeles, California 90095-1668

Received 26 April 2001/Accepted 31 August 2001

Myxococcus xanthus is a gram-negative soil bacterium that undergoes development under starvation conditions. Our previous study identified a new genetic locus, mrp, which is required for both fruiting body formation and sporulation. The locus encodes two transcripts: mrpAB, which consists of a histidine kinase and an NtrC-like response regulator, and mrpC, a cyclic AMP receptor protein family transcription activator. In this study, we used genetic and biochemical analyses to investigate the possible interactions between the mrp genes and other known developmental genes and events. These studies show that the mrp genes possibly function after A-signaling and (p)ppGpp but before C-signaling and that they regulate various early and late developmental genes and events.

* Corresponding author. Mailing address: UCLA Molecular Biology Institute and School of Dentistry, P.O. Box 951668, 10833 Le Conte Avenue, Los Angeles, CA 90095-1668. Phone: (310) 825-8356. Fax: (310) 794-7109. E-mail: wenyuan{at}ucla.edu.

Journal of Bacteriology, December 2001, p. 6733-6739, Vol. 183, No. 23
0021-9193/01/$04.00+0   DOI: 10.1128/JB.183.23.6733-6739.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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