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Journal of Bacteriology, December 2001, p. 6961-6964, Vol. 183, No. 23
0021-9193/01/$04.00+0   DOI: 10.1128/JB.183.23.6961-6964.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Carboxy-Terminal Region Involved in Activity of Escherichia coli TolC

Hiroyasu Yamanaka,1 Hiroshi Izawa,2 and Keinosuke Okamoto2,*

Department of Biochemistry, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro, Tokushima 770-8514,1 and Faculty of Pharmaceutical Sciences, Okayama University, Tsushima-naka, Okayama 700-8530,2 Japan

Received 29 June 2001/Accepted 10 September 2001

The Escherichia coli TolC acts as a channel tunnel in the transport of various molecules across the outer membrane. Partial-deletion studies of tolC revealed that the region extending from the 50th to the 60th amino acid residue from the carboxy terminus plays an important role in this transport activity of TolC.

* Corresponding author. Mailing address: Faculty of Pharmaceutical Sciences, Okayama University, Tsushima-naka, Okayama, Okayama 700-8530, Japan. Phone: 81-86-251-7945. Fax: 81-86-251-7927. E-mail: okamoto{at}pheasant.pharm.okayama-u.ac.jp.

Journal of Bacteriology, December 2001, p. 6961-6964, Vol. 183, No. 23
0021-9193/01/$04.00+0   DOI: 10.1128/JB.183.23.6961-6964.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • DeVito, J. A. (2008). Recombineering with tolC as a Selectable/Counter-selectable Marker: remodeling the rRNA Operons of Escherichia coli. Nucleic Acids Res 36: e4-e4 [Abstract] [Full Text]  
  • Augustus, A. M., Celaya, T., Husain, F., Humbard, M., Misra, R. (2004). Antibiotic-Sensitive TolC Mutants and Their Suppressors. J. Bacteriol. 186: 1851-1860 [Abstract] [Full Text]  


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