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Journal of Bacteriology, February 2001, p. 1455-1458, Vol. 183, No. 4
Department of Cell Membrane Biology,
Institute of Scientific and Industrial Research, Osaka University,
Ibaraki, Osaka 567-0047, Faculty of Pharmaceutical Science, Osaka
University, Suita, Osaka 565-0871, and CREST, Japan Science and
Technology Corporation, Osaka 567-0047, Japan
Received 14 August 2000/Accepted 16 November 2000
Overexpression of evgA, a response regulator of a
two-component system, increased multidrug efflux in Escherichia
coli. Since overexpression of the emrKY operon, which
is controlled by evgAS, could account only for deoxycholate
resistance, the evgAS locus apparently controls expression
of at least one other multidrug efflux operon.
0021-9193/01/$04.00+0 DOI: 10.1128/JB.183.4.1455-1458.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.
Overexpression of the Response Regulator
evgA of the Two-Component Signal Transduction System
Modulates Multidrug Resistance Conferred by Multidrug Resistance
Transporters
*
Corresponding author. Mailing address: Institute of
Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka,
Ibaraki-shi, Osaka 567-0047, Japan. Phone: 81-6-6879-8545. Fax:
81-6-6879-8549. E-mail:
akihito{at}sanken.osaka-u.ac.jp.
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