Proteins of Mycobacterium bovis BCG Induced in the Wayne Dormancy Model

doi:10.1128/JB.183.8.2672-2676.2001

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Journal of Bacteriology, April 2001, p. 2672-2676, Vol. 183, No. 8
0021-9193/01/$04.00+0 DOI: 10.1128/JB.183.8.2672-2676.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Proteins of Mycobacterium bovis BCG Induced in the Wayne Dormancy Model

Calvin Boon,¹ Rong Li,² Robert Qi,² and Thomas Dick¹^,^*

Mycobacterium Laboratory¹ and Proteomics Laboratory,² Institute of Molecular and Cell Biology, Singapore 117609, Republic of Singapore

Received 15 November 2000/Accepted 2 February 2001

Oxygen starvation triggers the shiftdown of the obligate aerobe Mycobacterium bovis BCG to a state of dormancy. Two-dimensionalelectrophoresis showed a drastic up-regulation of the $alpha$ -crystallinhomolog, the putative response regulator Rv3133c, and the twoconserved hypothetical proteins Rv2623 and Rv2626c in dormantbacilli.

^* Corresponding author. Mailing address: Institute of Molecular and Cell Biology, 30 Medical Dr., Singapore 117609, Republicof Singapore. Phone: 65-874-8606. Fax: 65-779-1117. E-mail: mcbtd{at}imcb.nus.edu.sg.

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