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Formation of dTDP-Rhamnose Is Essential for Growth of Mycobacteria

Department of Microbiology, Colorado State University, Fort Collins, Colorado 80523

Received 19 November 2001/ Accepted 20 March 2002

It was determined that the dTDP-rhamnose synthesis gene, rmlD, could be inactivated in Mycobacterium smegmatis only in the presence of a rescue plasmid carrying functional rmlD. Hence, dTDP-rhamnose biosynthesis is essential for the growth of mycobacteria and the targeting of dTDP-rhamnose synthesis for new tuberculosis drugs is supported.

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