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Journal of Bacteriology, June 2002, p. 3406-3410, Vol. 184, No. 12
0021-9193/02/$04.00+0     DOI: 10.1128/JB.184.12.3406-3410.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Catabolite Repression of Escherichia coli Biofilm Formation

Debra W. Jackson, Jerry W. Simecka, and Tony Romeo*

Department of Molecular Biology and Immunology, University of North Texas Health Science Center at Fort Worth, Fort Worth, Texas 76107-2699

Received 12 December 2001/ Accepted 24 March 2002

Biofilm formation was repressed by glucose in several species of Enterobacteriaceae. In Escherichia coli, this effect was mediated at least in part by cyclic AMP (cAMP)-cAMP receptor protein. A temporal role for cAMP in biofilm development was indicated by the finding that glucose addition after ~24 h failed to repress and generally activated biofilm formation.


* Corresponding author. Mailing address: Department of Molecular Biology and Immunology, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Blvd., Fort Worth, TX 76107-2699. Phone: (817) 735-2121. Fax: (817) 735-2118. E-mail: tromeo{at}hsc.unt.edu.


Journal of Bacteriology, June 2002, p. 3406-3410, Vol. 184, No. 12
0021-9193/02/$04.00+0     DOI: 10.1128/JB.184.12.3406-3410.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.




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