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Journal of Bacteriology, July 2002, p. 3749-3752, Vol. 184, No. 13
0021-9193/02/$04.00+0     DOI: 10.1128/JB.184.13.3749-3752.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Penicillin-Binding Proteins 1a and 1b Form Independent Dimers in Escherichia coli

Xavier Charpentier,1 Christian Chalut,1* Marie-Hélène Rémy,1 and Jean-Michel Masson1,2

Institut de Pharmacologie et de Biologie Structurale, UMR 5089 du CNRS,1 Institut National des Sciences Appliquées de Toulouse, Toulouse, France2

Received 14 January 2002/ Accepted 4 April 2002

We report here that PBP1a can dimerize but does not interact with PBP1b to form PBP1a/PBP1b heterodimers in Escherichia coli. These findings support the idea of a relevant involvement of dimerization of both PBP1a and PBP1b during murein synthesis and suggest the existence of different peptidoglycan synthesis complexes.

* Corresponding author. Mailing address: IPBS-CNRS, 205 route de Narbonne, 31077 Toulouse Cedex, France. Phone: (33) 0561 17 54 73. Fax: (33) 0561 17 59 94. E-mail: Christian.Chalut{at}ipbs.fr.

Journal of Bacteriology, July 2002, p. 3749-3752, Vol. 184, No. 13
0021-9193/02/$04.00+0     DOI: 10.1128/JB.184.13.3749-3752.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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