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Penicillin-Binding Proteins 1a and 1b Form Independent Dimers in Escherichia coli

Institut de Pharmacologie et de Biologie Structurale, UMR 5089 du CNRS,¹ Institut National des Sciences Appliquées de Toulouse, Toulouse, France²

Received 14 January 2002/ Accepted 4 April 2002

We report here that PBP1a can dimerize but does not interact with PBP1b to form PBP1a/PBP1b heterodimers in Escherichia coli. These findings support the idea of a relevant involvement of dimerization of both PBP1a and PBP1b during murein synthesis and suggest the existence of different peptidoglycan synthesis complexes.

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