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Journal of Bacteriology, August 2002, p. 4270-4276, Vol. 184, No. 15
0021-9193/02/$04.00+0     DOI: 10.1128/JB.184.15.4270-4276.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Structural and Genetic Analysis of the BldB Protein of Streptomyces coelicolor

Marcus Eccleston,1 Reem Ahmed Ali,1 Richard Seyler,2 Janet Westpheling,2 and Justin Nodwell1*

Antimicrobial Research Centre and Department of Biochemistry, McMaster University, Hamilton, Ontario, Canada L8N 3Z5,1 Department of Genetics, University of Georgia, Athens, Georgia 306022

Received 22 February 2002/ Accepted 29 April 2002

We have demonstrated that the bldB gene of Streptomyces coelicolor is required for the formation of aerial hyphae and the synthesis of antibiotics. We also found that BldB forms a higher-order complex (most likely a dimer) and that amino acid residues 20 to 78 are important for this interaction. This region is conserved in the BldB family, suggesting that dimer formation may be a common feature of these proteins.

* Corresponding author. Mailing address: Antimicrobial Research Centre and Department of Biochemistry, McMaster University, 1200 Main St. W, Hamilton, Ontario, Canada L8N 3Z5. Phone: (905) 525-9140, ext. 27335. Fax: (905) 522-9033. E-mail: nodwellj{at}mcmaster.ca.

Journal of Bacteriology, August 2002, p. 4270-4276, Vol. 184, No. 15
0021-9193/02/$04.00+0     DOI: 10.1128/JB.184.15.4270-4276.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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