This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lamanna, A. C.
Right arrow Articles by Kiessling, L. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lamanna, A. C.
Right arrow Articles by Kiessling, L. L.

 Previous Article  |  Next Article 

Journal of Bacteriology, September 2002, p. 4981-4987, Vol. 184, No. 18
0021-9193/02/$04.00+0     DOI: 10.1128/JB.184.18.4981-4987.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Conserved Amplification of Chemotactic Responses through Chemoreceptor Interactions

Allison C. Lamanna,1 Jason E. Gestwicki,1 Laura E. Strong,2,{dagger} Sara L. Borchardt,1 Robert M. Owen,2 and Laura L. Kiessling1,2*

Departments of Chemistry,2 Biochemistry, University of Wisconsin at Madison, Madison, Wisconsin 537061

Received 6 March 2002/ Accepted 6 June 2002

Many bacteria concentrate their chemoreceptors at the cell poles. Chemoreceptor location is important in Escherichia coli, since chemosensory responses are sensitive to receptor proximity. It is not known, however, whether chemotaxis in other bacteria is similarly regulated. To investigate the importance of receptor-receptor interactions in other bacterial species, we synthesized saccharide-bearing multivalent ligands that are designed to cluster relevant chemoreceptors. As has been shown with E. coli, we demonstrate that the behaviors of Bacillus subtilis, Spirochaete aurantia, and Vibrio furnissii are sensitive to the valence of the chemoattractant. Moreover, in B. subtilis, chemotactic responses to serine were increased by pretreatment with saccharide-bearing multivalent ligands. This result indicates that, as in E. coli, signaling information is transferred among chemoreceptors in B. subtilis. These results suggest that interreceptor communication may be a general mechanism for modulating chemotactic responses in bacteria.

* Corresponding author. Mailing address: Departments of Chemistry and Biochemistry, University of Wisconsin at Madison, 1101 University Ave., Madison, WI 53706. Phone: (608) 262-0541. Fax: (608) 265-0764. E-mail: kiessling{at}chem.wisc.edu.

{dagger} Present address: Quintessence Biosciences, Madison, WI 53719.

Journal of Bacteriology, September 2002, p. 4981-4987, Vol. 184, No. 18
0021-9193/02/$04.00+0     DOI: 10.1128/JB.184.18.4981-4987.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Stephens, B. B., Loar, S. N., Alexandre, G. (2006). Role of CheB and CheR in the Complex Chemotactic and Aerotactic Pathway of Azospirillum brasilense. J. Bacteriol. 188: 4759-4768 [Abstract] [Full Text]  
  • Shiomi, D., Banno, S., Homma, M., Kawagishi, I. (2005). Stabilization of Polar Localization of a Chemoreceptor via Its Covalent Modifications and Its Communication with a Different Chemoreceptor. J. Bacteriol. 187: 7647-7654 [Abstract] [Full Text]  
  • Lux, R., Shi, W. (2004). CHEMOTAXIS-GUIDED MOVEMENTS IN BACTERIA. CROBM 15: 207-220 [Abstract] [Full Text]  
  • Cabrera-Martinez, R.-M., Tovar-Rojo, F., Vepachedu, V. R., Setlow, P. (2003). Effects of Overexpression of Nutrient Receptors on Germination of Spores of Bacillus subtilis. J. Bacteriol. 185: 2457-2464 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»