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Journal of Bacteriology, October 2002, p. 5495-5501, Vol. 184, No. 19
0021-9193/02/$04.00+0     DOI: 10.1128/JB.184.19.5495-5501.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Chromosomal Amplification of the Escherichia coli lipB Region Confers High-Level Resistance to Selenolipoic Acid

Sean W. Jordan1 and John E. Cronan, Jr.1,2*

Departments of Microbiology,1 Biochemistry, University of Illinois, Urbana, Illinois 618012

Received 6 May 2002/ Accepted 3 July 2002

One of the mutants (slr7 mutant) of a wild-type Escherichia coli strain resistant to selenolipoic acid reported previously (K. E. Reed, T. W. Morris, and J. E. Cronan, Jr., Proc. Natl. Acad. Sci. USA 91:3720-3724, 1994) unexpectedly grew on minimal medium following transductional introduction of a lipA null mutation. We report that the slr7 strain carries a duplication of the lip chromosomal region that causes the phenotype of the mutant strain.

* Corresponding author. Mailing address: Department of Microbiology, University of Illinois, B103 Chemical and Life Sciences Laboratory, 601 S. Goodwin Ave., Urbana, IL 61801. Phone: (217) 333-7919. Fax: (217) 244-6697. E-mail: j-cronan{at}life.uiuc.edu.

Journal of Bacteriology, October 2002, p. 5495-5501, Vol. 184, No. 19
0021-9193/02/$04.00+0     DOI: 10.1128/JB.184.19.5495-5501.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.





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