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Journal of Bacteriology, October 2002, p. 5513-5517, Vol. 184, No. 19
0021-9193/02/$04.00+0     DOI: 10.1128/JB.184.19.5513-5517.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

The Escherichia coli metD Locus Encodes an ABC Transporter Which Includes Abc (MetN), YaeE (MetI), and YaeC (MetQ)

Christophe Merlin, Gregory Gardiner, Sylvain Durand, and Millicent Masters*

University of Edinburgh, Institute for Cell and Molecular Biology, Edinburgh EH9 3JR, Scotland

Received 4 March 2002/ Accepted 2 July 2002

We report that the genes abc, yaeC, and yaeE comprise metD, an Escherichia coli locus encoding a DL-methionine uptake system. MetD is an ABC transporter with Abc the ATPase, YaeE the permease, and YaeC the likely substrate binding protein. Expression of these genes is regulated by L-methionine and MetJ, a common repressor of the methionine regulon. We propose to rename abc, yaeE, and yaeC as metN, metI, and metQ, respectively.

* Corresponding author. Mailing address: University of Edinburgh, Institute of Cell and Molecular Biology, Darwin Building, King's Buildings, Mayfield Rd., Edinburgh EH9 3JR, Scotland. Phone: 44 (0)131 650 5355. Fax: 44 (0)131 650 8650. E-mail: M.Masters{at}ed.ac.uk.

Journal of Bacteriology, October 2002, p. 5513-5517, Vol. 184, No. 19
0021-9193/02/$04.00+0     DOI: 10.1128/JB.184.19.5513-5517.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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