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Journal of Bacteriology, January 2002, p. 572-576, Vol. 184, No. 2
0021-9193/01/$04.00+0     DOI: 10.1128/JB.184.2.572-576.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

VmrA, a Member of a Novel Class of Na+-Coupled Multidrug Efflux Pumps from Vibrio parahaemolyticus

Jing Chen, Yuji Morita, M. Nazmul Huda, Teruo Kuroda, Tohru Mizushima, and Tomofusa Tsuchiya*

Department of Microbiology, Faculty of Pharmaceutical Sciences, Okayama University, Tsushima, Okayama 700-8530, Japan

Received 26 July 2001/ Accepted 18 October 2001

Gene vmrA, cloned from Vibrio parahaemolyticus, made Escherichia coli resistant to 4prime;,6-diamino-2-phenylindol, tetraphenylphosphonium chloride, acriflavine, and ethidium bromide. VmrA belongs to the DinF branch of MATE family efflux transporters. VmrA catalyzed acriflavine efflux and showed Na+/drug transporter activity because the addition of tetraphenylphosphonium to Na+-loaded cells caused Na+ efflux.

* Corresponding author. Mailing address: Department of Microbiology, Faculty of Pharmaceutical Sciences, Okayama University, Tsushima, Okayama 700-8530, Japan. Phone: 81(86) 251-7957. Fax: 81(86) 251-7957. E-mail: tsuchiya{at}pharm.okayama-u.ac.jp.

Journal of Bacteriology, January 2002, p. 572-576, Vol. 184, No. 2
0021-9193/01/$04.00+0     DOI: 10.1128/JB.184.2.572-576.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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