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Journal of Bacteriology, January 2002, p. 605-609, Vol. 184, No. 2
0021-9193/01/$04.00+0     DOI: 10.1128/JB.184.2.605-609.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

High Frequency of Mutator Strains among Human Uropathogenic Escherichia coli Isolates

Erick Denamur,1 Stéphane Bonacorsi,2 Antoine Giraud,3 Patrick Duriez,1,3 Farida Hilali,4 Christine Amorin,1 Edouard Bingen,2 Antoine Andremont,4 Bertrand Picard,5 François Taddei,3 and Ivan Matic3*

INSERM U 458,1 Laboratoire d’Étude de Génétique Bactérienne dans les Infections de l’Enfant (EA3105),2 Hôpital Robert Debré, INSERM EPI 9916, Faculté de Médecine Necker-Enfants Malades, Université René Descartes—Paris V,3 INSERM EPI 9933, Hôpital Bichat-Claude Bernard, AP-HP, Paris,4 Laboratoire de Microbiologie, Hôpital Morvan, Brest, France5

Received 18 June 2001/ Accepted 24 October 2001

By using a panel of 603 commensal and pathogenic Escherichia coli and Shigella isolates, we showed that mutation rates of strains vary considerably among different ecotypes. Uropathogenic strains had the highest frequency of mutators, while strains from patients with bacteremia had the lowest mutation rates. No correlation between the mutation rates and antibiotic resistance was observed among the studied strains.

* Corresponding author. Mailing address: INSERM EPI 9916, Faculté de Médecine Necker-Enfants Malades, Université Rene Descartes—Paris V, 156 Rue de Vaugirard, 75730 Paris Cedex 15, France. Phone: (33) 1 40 61 53 25. Fax: (33) 1 40 61 53 22. E-mail: matic{at}necker.fr.

Journal of Bacteriology, January 2002, p. 605-609, Vol. 184, No. 2
0021-9193/01/$04.00+0     DOI: 10.1128/JB.184.2.605-609.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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