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Journal of Bacteriology, October 2002, p. 5789-5799, Vol. 184, No. 20
0021-9193/02/$04.00+0     DOI: 10.1128/JB.184.20.5789-5799.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Conserved Response Regulator CtrA and IHF Binding Sites in the {alpha}-Proteobacteria Caulobacter crescentus and Rickettsia prowazekii Chromosomal Replication Origins

Ann Karen C. Brassinga,1 Rania Siam,2 William McSween,3 Herbert Winkler,3 David Wood,3 and Gregory T. Marczynski4*

Department of Microbiology & Immunology, Dalhousie University, Halifax, Nova Scotia B3H 4H7, Canada,1 Molecular and Cellular Biology Laboratory, The Salk Institute for Biological Sciences, La Jolla, California 92037-1099,2 Department of Microbiology and Immunology, College of Medicine, University of South Alabama, Mobile, Alabama 36688,3 Department of Microbiology & Immunology, McGill University, Montreal, Quebec H3A 2B4, Canada4

Received 28 March 2002/ Accepted 10 July 2002

CzcR is the Rickettsia prowazekii homolog of the Caulobacter crescentus global response regulator CtrA. CzcR expression partially compensates for developmental defects in ctrA mutant C. crescentus cells, and CzcR binds to all five CtrA binding sites in the C. crescentus replication origin. Conversely, CtrA binds to five similar sites in the putative R. prowazekii replication origin (oriRp). Also, Escherichia coli IHF protein binds over a central CtrA binding site in oriRp. Therefore, CtrA and IHF regulatory proteins have similar binding patterns in both replication origins, and we propose that CzcR is a global cell cycle regulator in R. prowazekii.

* Corresponding author. Mailing address: Department of Microbiology & Immunology, Lyman-Duff Building, Rm. 506, McGill University, 3775 University Street, Montreal, Quebec H3A 2B4, Canada. Phone: (514) 398-3917. Fax: (514) 398-7052. E-mail: gmarczynski{at}microimm.mcgill.ca.

Journal of Bacteriology, October 2002, p. 5789-5799, Vol. 184, No. 20
0021-9193/02/$04.00+0     DOI: 10.1128/JB.184.20.5789-5799.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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