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Journal of Bacteriology, November 2002, p. 6081-6083, Vol. 184, No. 21
0021-9193/02/$04.00+0     DOI: 10.1128/JB.184.21.6081-6083.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

A Gene Encoding a Homologue of Dolichol Phosphate-ß-D-Mannose Synthase Is Required for Infection of Streptomyces coelicolor A3(2) by Phage C31

Institute of Genetics, University of Nottingham, Queens Medical Centre, Nottingham NG7 2UH, United Kingdom

Received 3 May 2002/ Accepted 1 August 2002

We have shown previously that a gene encoding a homologue to the eukaryotic dolichol-phosphate-D-mannose, protein O-D-mannosyltransferase, was required for C31 infection of Streptomyces coelicolor. Here we show that a gene encoding the homologue to dolichol-phosphate-mannose synthase is also essential for phage sensitivity. These data confirm the role of glycosylation in the phage receptor for C31 in S. coelicolor.

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