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Journal of Bacteriology, November 2002, p. 6389-6394, Vol. 184, No. 22
0021-9193/02/$04.00+0     DOI: 10.1128/JB.184.22.6389-6394.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Bex, the Bacillus subtilis Homolog of the Essential Escherichia coli GTPase Era, Is Required for Normal Cell Division and Spore Formation

Natalie Minkovsky,1 Arash Zarimani,2,{dagger} Vasant K. Chary,1 Brian H. Johnstone,2,{ddagger} Bradford S. Powell,3,§ Pamela D. Torrance,2,|| Donald L. Court,3 Robert W. Simons,2 and Patrick J. Piggot1*

Department of Microbiology and Immunology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140,1 Department of Microbiology, Immunology and Molecular Genetics, University of California at Los Angeles, Los Angeles, California 90095,2 Gene Regulation and Chromosome Biology Laboratory, Division of Basic Sciences, National Cancer Institute at Frederick, Frederick, Maryland 217023

Received 13 May 2002/ Accepted 23 August 2002

The Bacillus subtilis bex gene complemented the defect in an Escherichia coli era mutant. The Bex protein showed 39% identity and 67% similarity to the E. coli Era GTPase. In contrast to era, bex was not essential in all strains. bex mutant cells were elongated and filled with diffuse nucleoid material. They grew slowly and exhibited severely impaired spore formation.

* Corresponding author. Mailing address: Department of Microbiology and Immunology, Temple University School of Medicine, 3400 N. Broad St., Philadelphia, PA 19140. Phone: (215) 707-7927. Fax: (215) 707-7788. E-mail: piggotp{at}temple.edu.

{dagger} Present address: Department of Medicine, Duke University Medical Center, Durham, NC 27710.

{ddagger} Present address: Sangamo Biosciences, Richmond, CA 94804.

§ Present address: Bacteriology Division, USAMRIID, Frederick, MD 21702.

|| Present address: Genlab Technologies, Redwood City, CA 94063.

Journal of Bacteriology, November 2002, p. 6389-6394, Vol. 184, No. 22
0021-9193/02/$04.00+0     DOI: 10.1128/JB.184.22.6389-6394.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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