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Journal of Bacteriology, February 2002, p. 1112-1120, Vol. 184, No. 4
0021-9193/01/$04.00+0     DOI: 10.1128/jb.184.4.1112-1120.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Chromosomal Locus That Affects Pathogenicity of Rhodococcus fascians

Danny Vereecke,1 Karen Cornelis,1 Wim Temmerman,1 Mondher Jaziri,2 Marc Van Montagu,1 Marcelle Holsters,1* and Koen Goethals1

Vakgroep Moleculaire Genetica, Departement Plantengenetica, Vlaams Interuniversitair Instituut voor Biotechnologie, Universiteit Gent, B-9000 Ghent, Belgium,1 Laboratoire de Biotechnologie Végétale, Université Libre de Bruxelles, B-1160 Brussels, Belgium2

Received 15 June 2001/ Accepted 12 November 2001

The gram-positive plant pathogen Rhodococcus fascians provokes leafy gall formation on a wide range of plants through secretion of signal molecules that interfere with the hormone balance of the host. Crucial virulence genes are located on a linear plasmid, and their expression is tightly controlled. A mutant with a mutation in a chromosomal locus that affected virulence was isolated. The mutation was located in gene vicA, which encodes a malate synthase and is functional in the glyoxylate shunt of the Krebs cycle. VicA is required for efficient in planta growth in symptomatic, but not in normal, plant tissue, indicating that the metabolic requirement of the bacteria or the nutritional environment in plants or both change during the interaction. We propose that induced hyperplasia on plants represents specific niches for the causative organisms as a result of physiological alterations in the symptomatic tissue. Hence, such interaction could be referred to as metabolic habitat modification.

* Corresponding author. Mailing address: Vakgroep Moleculaire Genetica, Universiteit Gent, K.L. Ledeganckstraat 35, B-9000 Ghent, Belgium. Phone: (32 9) 264 5181. Fax: (32 9) 246 5349. E-mail: mahol{at}gengenp.rug.ac.be.

Journal of Bacteriology, February 2002, p. 1112-1120, Vol. 184, No. 4
0021-9193/01/$04.00+0     DOI: 10.1128/jb.184.4.1112-1120.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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