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Journal of Bacteriology, February 2002, p. 1209-1213, Vol. 184, No. 4
0021-9193/01/$04.00+0     DOI: 10.1128/jb.184.4.1209-1213.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

FimZ Is a Molecular Link between Sticking and Swimming in Salmonella enterica Serovar Typhimurium

Steven Clegg1* and Kelly T. Hughes2

Department of Microbiology, College of Medicine, University of Iowa, Iowa City, Iowa 52242 ,1 Department of Microbiology, University of Washington, Seattle, Washington 981952

Received 3 August 2001/ Accepted 26 November 2001

Salmonella enterica serovar Typhimurium produces two types of filamentous appendages on its surface. Fimbriae mediate adherence to tissues and cells via receptor-specific interactions, and flagella are the organelles of motility. These appendages play a role in colonization and dissemination, respectively, from infected surfaces and may be important components of bacterial survival. Increased expression of FimZ in serovar Typhimurium resulted in bacteria which were hyperfimbriated but were nonmotile in soft agar. This lack of motility was associated with down regulation of the flhDC master flagellar operon. Therefore, FimZ represents a molecular connection between flagella and fimbrial formation in serovar Typhimurium, indicating that the synthesis of flagella and fimbriae are oppositely controlled.

* Corresponding author. Mailing address: Department of Microbiology, College of Medicine, University of Iowa, Iowa City, IA 52242. Phone: (319) 335-7778. Fax: (319) 335-9006. E-mail: steven-clegg{at}uiowa.edu.

Journal of Bacteriology, February 2002, p. 1209-1213, Vol. 184, No. 4
0021-9193/01/$04.00+0     DOI: 10.1128/jb.184.4.1209-1213.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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