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Journal of Bacteriology, April 2002, p. 2310-2313, Vol. 184, No. 8
0021-9193/02/$04.00+0     DOI: 10.1128/JB.184.8.2310-2313.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

A MecA Paralog, YpbH, Binds ClpC, Affecting both Competence and Sporulation

Marjan Persuh,1,2 Ines Mandic-Mulec,2 and David Dubnau1*

Public Health Research Institute, New York, New York 10016,1 University of Ljubljana, 1000 Ljubljana, Slovenia2

Received 14 November 2001/ Accepted 26 January 2002

ComK, the master regulator of competence, is degraded by the general stress-related protease ClpCP but must be targeted to this protease by binding to the adapter protein MecA. The genome of Bacillus subtilis contains a paralog of mecA, ypbH. We show in the present study that YpbH, like MecA, binds ClpC and that its elimination or overproduction affects competence and sporulation.

* Corresponding author. Mailing address: Public Health Research Institute, 455 First Ave., New York, NY 10016. Phone and fax: (212) 578-0804. E-mail: dubnau{at}phri.nyu.edu.

Journal of Bacteriology, April 2002, p. 2310-2313, Vol. 184, No. 8
0021-9193/02/$04.00+0     DOI: 10.1128/JB.184.8.2310-2313.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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