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Journal of Bacteriology, April 2002, p. 2314-2318, Vol. 184, No. 8
0021-9193/02/$04.00+0     DOI: 10.1128/JB.184.8.2314-2318.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Prediction of Gene Function in Methylthioadenosine Recycling from Regulatory Signals

Brooke A. Murphy, Frank J. Grundy, and Tina M. Henkin*

Department of Microbiology, The Ohio State University, Columbus, Ohio 43210

Received 29 August 2001/ Accepted 22 January 2002

The S-box transcription termination control system, first identified in Bacillus subtilis, is used for regulation of gene expression in response to methionine availability. The presence of the S-box motif provided the first indication that the ykrTS and ykrWXYZ genes could play a role in recycling of 5'-methylthioadenosine, a by-product of polyamine biosynthesis that can be converted to methionine. In this study we demonstrate a role for the ykrTS and ykrWXYZ gene products in this pathway.


* Corresponding author. Mailing address: Department of Microbiology, The Ohio State University, 484 West 12th Ave., Columbus, OH 43210. Phone: (614) 688-3831. Fax: (614) 292-8120. E-mail: henkin.3{at}osu.edu.


Journal of Bacteriology, April 2002, p. 2314-2318, Vol. 184, No. 8
0021-9193/02/$04.00+0     DOI: 10.1128/JB.184.8.2314-2318.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.




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