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Journal of Bacteriology, April 2002, p. 2319-2323, Vol. 184, No. 8
0021-9193/02/$04.00+0     DOI: 10.1128/JB.184.8.2319-2323.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

EvgA of the Two-Component Signal Transduction System Modulates Production of the YhiUV Multidrug Transporter in Escherichia coli

Kunihiko Nishino and Akihito Yamaguchi*

Department of Cell Membrane Biology, Institute of Scientific and Industrial Research, Osaka University, Ibaraki, Osaka 567-0047, Faculty of Pharmaceutical Science, Osaka University, Suita, Osaka 565-0871, and CREST, Japan Science and Technology Corporation, Osaka 567-0047, Japan

Received 28 September 2001/ Accepted 8 January 2002

Overexpression of the EvgA regulator of the two-component signal transduction system was previously found to modulate multidrug resistance of Escherichia coli by increasing efflux of drugs (K. Nishino and A. Yamaguchi, J. Bacteriol. 183:1455-1458, 2001). Here we present data showing that EvgA contributes to multidrug resistance through increased expression of the multidrug transporter yhiUV gene.

* Corresponding author. Mailing address: Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki-shi, Osaka 567-0047, Japan. Phone: 81-6-6879-8545. Fax: 81-6-6879-8549. E-mail: akihito{at}sanken.osaka-u.ac.jp.

Journal of Bacteriology, April 2002, p. 2319-2323, Vol. 184, No. 8
0021-9193/02/$04.00+0     DOI: 10.1128/JB.184.8.2319-2323.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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