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Journal of Bacteriology, May 2002, p. 2543-2545, Vol. 184, No. 9
0021-9193/02/$04.00+0     DOI: 10.1128/JB.184.9.2543-2545.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Overexpression of the Escherichia coli sugE Gene Confers Resistance to a Narrow Range of Quaternary Ammonium Compounds

Yong Joon Chung,{dagger} and Milton H. Saier, Jr.*

Division of Biology, University of California at San Diego, La Jolla, California 92093-0116

Received 10 December 2001/ Accepted 8 February 2002

SugE of Escherichia coli, first identified as a suppressor of groEL mutations but a member of the small multidrug resistance family, has not previously been shown to confer a drug resistance phenotype. We show that high-level expression of sugE leads to resistance to a subset of toxic quaternary ammonium compounds.

* Corresponding author. Mailing address: Division of Biology, University of California at San Diego, La Jolla, CA 92093-0116. Phone: (858) 534-4084. Fax: (858) 534-7108. E-mail: msaier{at}ucsd.edu.

{dagger} Permanent address: Department of Life Science, Jeonju University, Chonju, Korea.

Journal of Bacteriology, May 2002, p. 2543-2545, Vol. 184, No. 9
0021-9193/02/$04.00+0     DOI: 10.1128/JB.184.9.2543-2545.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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