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Journal of Bacteriology, May 2002, p. 2546-2551, Vol. 184, No. 9
0021-9193/02/$04.00+0     DOI: 10.1128/JB.184.9.2546-2551.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Analysis of the Heat Shock Response of Neisseria meningitidis with cDNA- and Oligonucleotide-Based DNA Microarrays

Matthias Guckenberger,1 Sebastian Kurz,1 Christian Aepinus,1 Stephanie Theiss,1 Sabine Haller,1 Thomas Leimbach,1 Ursula Panzner,1 Jacqueline Weber,2 Hubert Paul,2 Alexandra Unkmeir,1 Matthias Frosch,1* and Guido Dietrich1,{dagger}

Institute for Hygiene and Microbiology, University of Würzburg, 97080 Würzburg,1 MWG-Biotech AG, 85560 Ebersberg, Germany2

Received 10 October 2001/ Accepted 9 January 2002

Oligonucleotide- and cDNA-based microarrays comprising a subset of Neisseria meningitidis genes were assessed for study of the meningococcal heat shock response and found to be highly suitable for transcriptional profiling of N. meningitidis. Employing oligonucleotide arrays encompassing the entire genome of N. meningitidis, we analyzed the meningococcal heat shock response on a global scale and identified 55 heat shock-deregulated open reading frames (34 induced and 21 repressed).

* Corresponding author. Mailing address: Institute for Hygiene and Microbiology, University of Würzburg, Josef-Schneider-Str. 2, 97080 Würzburg, Germany. Phone: 49-931-201-5161. Fax: 49-931-201-3445. E-mail: mfrosch{at}hygiene.uni-wuerzburg.de.

{dagger} Present address: Berna Biotech AG, Bacterial Vaccine Research, 3018 Berne, Switzerland.

Journal of Bacteriology, May 2002, p. 2546-2551, Vol. 184, No. 9
0021-9193/02/$04.00+0     DOI: 10.1128/JB.184.9.2546-2551.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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