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Journal of Bacteriology, July 2003, p. 4276-4279, Vol. 185, No. 14
0021-9193/03/$08.00+0     DOI: 10.1128/JB.185.14.4276-4279.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Structural Insight into the Antibiotic Action of Telithromycin against Resistant Mutants

Rita Berisio,1,{dagger} Joerg Harms,1 Frank Schluenzen,1 Raz Zarivach,2 Harly A. S. Hansen,1 Paola Fucini,3 and Ada Yonath2*

Max-Planck-Research Unit for Ribosomal Structure, Hamburg,1 Max-Planck-Institute for Molecular Genetics, Berlin, Germany,3 Department of Structural Biology, Weizmann Institute of Science, Rehovot, Israel2

Received 6 February 2003/ Accepted 1 May 2003

The crystal structure of the ketolide telithromycin bound to the Deinococcus radiodurans large ribosomal subunit shows that telithromycin blocks the ribosomal exit tunnel and interacts with domains II and V of the 23S RNA. Comparisons to other clinically relevant macrolides provided structural insights into its enhanced activity against macrolide-resistant strains.

* Corresponding author. Mailing address: Department of Structural Biology, The Weizmann Institute of Science, Rehovot 76100, Israel. Phone: 972 8 934 3028 or 2541. Fax: 972 8 934 4154 or 4136. E-mail: ada.yonath{at}weizmann.ac.il.

{dagger} Permanent address: Institute of Biostructure and Bioimaging, CNR, Naples, Italy.

Journal of Bacteriology, July 2003, p. 4276-4279, Vol. 185, No. 14
0021-9193/03/$08.00+0     DOI: 10.1128/JB.185.14.4276-4279.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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