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Journal of Bacteriology, August 2003, p. 4558-4563, Vol. 185, No. 15
0021-9193/03/$08.00+0     DOI: 10.1128/JB.185.15.4558-4563.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Phase Variation in the Phage Growth Limitation System of Streptomyces coelicolor A3(2)

Paul Sumby{dagger} and Margaret C. M. Smith*

Institute of Genetics, University of Nottingham, Queens Medical Centre, Nottingham, NG7 2UH, United Kingdom

Received 28 February 2003/ Accepted 9 May 2003

The phase-variable phage growth limitation (Pgl) system of Streptomyces coelicolor A3(2) is an unusual bacteriophage resistance mechanism that confers protection against the temperate phage {phi}C31 and homoimmune relatives. Pgl is subject to phase variation, and data presented here show that this is at least partially due to expansion and contraction of a polyguanine tract present within the putative adenine-specific DNA methyltransferase gene, pglX. Furthermore, the pglX paralogue SC6G9.02, here renamed pglS, was shown to be able to interfere with the Pgl phenotype, suggesting that PglS could provide an alternative activity to that conferred by PglX.

* Corresponding author. Mailing address: Institute of Genetics, University of Nottingham, Queens Medical Centre, Nottingham, NG7 2UH, United Kingdom. Phone: (44) 115 970 9778. Fax: (44) 115 970 9906. E-mail: maggie.smith{at}nottingham.ac.uk.

{dagger} Present address: Division of Geographic Medicine and Infectious Diseases, Tufts New England Medical Center, Boston, MA 02111.

Journal of Bacteriology, August 2003, p. 4558-4563, Vol. 185, No. 15
0021-9193/03/$08.00+0     DOI: 10.1128/JB.185.15.4558-4563.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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