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Journal of Bacteriology, August 2003, p. 4630-4637, Vol. 185, No. 15
0021-9193/03/$08.00+0     DOI: 10.1128/JB.185.15.4630-4637.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

A 65-Kilobase Pathogenicity Island Is Unique to Philadelphia-1 Strains of Legionella pneumophila

Department of Microbiology and Immunology,¹ Division of Infectious Diseases, Department of Medicine, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4H7,³ Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104-4283²

Received 31 March 2003/ Accepted 12 May 2003

Nucleotide sequence analysis of an 80-kb genomic region revealed an 65-kb locus that bears hallmarks of a pathogenicity island. This locus includes homologues of a type IV secretion system, mobile genetic elements, and known virulence factors. Comparative studies with other Legionella pneumophila strains and serogroups indicated that this 65-kb locus is unique to L. pneumophila serogroup 1 Philadelphia-1 strains.

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