This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Marokhazi, J. Articles by ffrench-Constant, R. H. Search for Related Content PubMed PubMed Citation Articles by Marokhazi, J. Articles by ffrench-Constant, R. H.

 Previous Article  |  Next Article 

Journal of Bacteriology, August 2003, p. 4648-4656, Vol. 185, No. 15
0021-9193/03/$08.00+0     DOI: 10.1128/JB.185.15.4648-4656.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Using a DNA Microarray To Investigate the Distribution of Insect Virulence Factors in Strains of Photorhabdus Bacteria

Judit Marokhazi,^1,2 Nicholas Waterfield,¹ Gaelle LeGoff,¹ Edward Feil,¹ Richard Stabler,³ Jason Hinds,³ Andras Fodor,⁴ and Richard H. ffrench-Constant^1*

Department of Biology and Biochemistry, University of Bath, Bath, BA2 7AY,¹ Bacterial Microarray Group, Department of Medical Microbiology, St George's Hospital Medical School, London, SW17 0RE, United Kingdom,³ Departments of Biochemistry,² Genetics, Eotvos Lorand University, Budapest, Hungary⁴

Received 19 February 2003/ Accepted 5 May 2003

Photorhabdus is an insect-pathogenic bacterium in which oral toxicity to insects is found in two distinct taxonomic groups. Using a DNA microarray and comparative genomics, we show that oral toxicity is associated with toxin complex genes tcaABC and that this locus can be mobilized or deleted within different strains.

---

* Corresponding author. Mailing address: Department of Biology and Biochemistry, University of Bath, Bath, BA2 7AY, United Kingdom. Phone: 44 1225 386261. Fax: 44 1225 386779. E-mail: bssrfc{at}bath.ac.uk.

---

Journal of Bacteriology, August 2003, p. 4648-4656, Vol. 185, No. 15
0021-9193/03/$08.00+0     DOI: 10.1128/JB.185.15.4648-4656.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

This article has been cited by other articles:

• Eleftherianos, I., Boundy, S., Joyce, S. A., Aslam, S., Marshall, J. W., Cox, R. J., Simpson, T. J., Clarke, D. J., ffrench-Constant, R. H., Reynolds, S. E. (2007). An antibiotic produced by an insect-pathogenic bacterium suppresses host defenses through phenoloxidase inhibition. Proc. Natl. Acad. Sci. USA 104: 2419-2424 [Abstract] [Full Text]  
• Lindroos, H. L., Mira, A., Repsilber, D., Vinnere, O., Naslund, K., Dehio, M., Dehio, C., Andersson, S. G. E. (2005). Characterization of the Genome Composition of Bartonella koehlerae by Microarray Comparative Genomic Hybridization Profiling. J. Bacteriol. 187: 6155-6165 [Abstract] [Full Text]  
• Stabler, R. A., Marsden, G. L., Witney, A. A., Li, Y., Bentley, S. D., Tang, C. M., Hinds, J. (2005). Identification of pathogen-specific genes through microarray analysis of pathogenic and commensal Neisseria species. Microbiology 151: 2907-2922 [Abstract] [Full Text]  
• Cabral, C. M., Cherqui, A., Pereira, A., Simoes, N. (2004). Purification and Characterization of Two Distinct Metalloproteases Secreted by the Entomopathogenic Bacterium Photorhabdus sp. Strain Az29. Appl. Environ. Microbiol. 70: 3831-3838 [Abstract] [Full Text]  
• Brugirard-Ricaud, K., Givaudan, A., Parkhill, J., Boemare, N., Kunst, F., Zumbihl, R., Duchaud, E. (2004). Variation in the Effectors of the Type III Secretion System among Photorhabdus Species as Revealed by Genomic Analysis. J. Bacteriol. 186: 4376-4381 [Abstract] [Full Text]