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Journal of Bacteriology, August 2003, p. 5015-5018, Vol. 185, No. 16
0021-9193/03/$08.00+0     DOI: 10.1128/JB.185.16.5015-5018.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Escherichia coli Cells Bearing a Ribosomal Ambiguity Mutation in rpsD Have a Mutator Phenotype That Correlates with Increased Mistranslation

Sergey Balashov and M. Zafri Humayun*

University of Medicine and Dentistry of New Jersey—New Jersey Medical School, Department of Microbiology and Molecular Genetics, International Center for Public Health, Newark, New Jersey 07101-1709

Received 18 March 2003/ Accepted 23 May 2003

Escherichia coli cells bearing certain mutations in rpsD (coding for the 30S ribosomal protein S4) show a ribosomal ambiguity (Ram) phenotype characterized by increased translational error rates. Here we show that spontaneous mutagenesis increases in Ram cells bearing the rpsD14 allele, suggesting that the recently described translational stress-induced mutagenesis pathway is activated in Ram cells.

* Corresponding author. Mailing address: UMDNJ—New Jersey Medical School, Department of Microbiology and Molecular Genetics, International Center for Public Health, 225 Warren St., Newark, NJ 07101-1709. Phone: (973) 972-4483, ext. 2-6396. Fax: (973) 972-8982. E-mail: humayun{at}umdnj.edu.

Journal of Bacteriology, August 2003, p. 5015-5018, Vol. 185, No. 16
0021-9193/03/$08.00+0     DOI: 10.1128/JB.185.16.5015-5018.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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