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Journal of Bacteriology, September 2003, p. 5287-5289, Vol. 185, No. 17
0021-9193/03/$08.00+0     DOI: 10.1128/JB.185.17.5287-5289.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Efflux of Cytoplasmically Acting Antibiotics from Gram-Negative Bacteria: Periplasmic Substrate Capture by Multicomponent Efflux Pumps Inferred from Their Cooperative Action with Single-Component Transporters

Michael Palmer*

Department of Chemistry, University of Waterloo, Waterloo, Ontario, N2L 3G1, Canada

Received 14 April 2003/ Accepted 10 June 2003

In gram-negative bacteria, coexpression of single- and multicomponent efflux pumps may result in multiplicative enhancement of the level of resistance against cytoplasmically acting antibiotics. Here, a simple model is presented to show that this cooperative effect can be accounted for only if substrate capture by the multicomponent efflux transporter occurs in the periplasm but not the cytosol.

* Mailing address: Department of Chemistry, University of Waterloo, 200 University Ave. West, Waterloo, Ontario N2L 3G1, Canada. Phone: 519 888 4567 5100. Fax: 519 746 0435. E-mail: mpalmer{at}uwaterloo.ca.

Journal of Bacteriology, September 2003, p. 5287-5289, Vol. 185, No. 17
0021-9193/03/$08.00+0     DOI: 10.1128/JB.185.17.5287-5289.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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