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Journal of Bacteriology, September 2003, p. 5314-5319, Vol. 185, No. 17
0021-9193/03/$08.00+0     DOI: 10.1128/JB.185.17.5314-5319.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

IS1999 Increases Expression of the Extended-Spectrum ß-Lactamase VEB-1 in Pseudomonas aeruginosa

Daniel Aubert, Thierry Naas,* and Patrice Nordmann

Service de Bactériologie-Virologie, Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine Paris-Sud, 94275 Le Kremlin-Bicêtre Cedex, France

Received 2 April 2003/ Accepted 5 June 2003

The integron-borne blaVEB-1 gene encodes an extended-spectrum ß-lactamase. This gene was associated mostly with IS1999 and rarely with an additional IS2000 element in Pseudomonas aeruginosa isolates from Thailand, whereas IS1999 was only very rarely associated with blaVEB-1 in Enterobacteriaceae. Expression experiments and promoter study identified promoter sequences in IS1999 that increased the expression of VEB-1 in P. aeruginosa.

* Corresponding author. Mailing address: Service de Bactériologie-Virologie, Hôpital de Bicêtre, 78 rue du Général Leclerc, 94275 Le Kremlin-Bicêtre Cedex, France. Phone: 33-1-45-21-29-86. Fax: 33-1-45-21-63-40. E-mail. thierry.naas{at}bct.ap-hop-paris.fr.

Journal of Bacteriology, September 2003, p. 5314-5319, Vol. 185, No. 17
0021-9193/03/$08.00+0     DOI: 10.1128/JB.185.17.5314-5319.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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  • Aubert, D., Naas, T., Heritier, C., Poirel, L., Nordmann, P. (2006). Functional Characterization of IS1999, an IS4 Family Element Involved in Mobilization and Expression of {beta}-Lactam Resistance Genes.. J. Bacteriol. 188: 6506-6514 [Abstract] [Full Text]  
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