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Periodicity of Cell Attachment Patterns during Escherichia coli Biofilm Development

Konstantin Agladze,¹ Debra Jackson,^2, and Tony Romeo^1*

Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia 30322,¹ Department of Molecular Biology and Immunology, University of North Texas Health Science Center at Fort Worth, Fort Worth, Texas 76107²

Received 14 April 2003/ Accepted 24 June 2003

The complex architecture of bacterial biofilms inevitably raises the question of their design. Microstructure of developing Escherichia coli biofilms was analyzed under static and laminar flow conditions. Cell attachment during early biofilm formation exhibited periodic density patterns that persisted during development. Several models for the origination of biofilm microstructure are considered, including an activator-inhibitor or Turing model.

Present address: Department of Microbiology and Immunology, Program in Molecular Pathogenesis and Immunity, Tulane University Health Sciences Center, New Orleans, LA 70112-2699.

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