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Journal of Bacteriology, September 2003, p. 5648-5653, Vol. 185, No. 18
0021-9193/03/$08.00+0     DOI: 10.1128/JB.185.18.5648-5653.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Irp9, Encoded by the High-Pathogenicity Island of Yersinia enterocolitica, Is Able To Convert Chorismate into Salicylate, the Precursor of the Siderophore Yersiniabactin

Cosima Pelludat,1 Daniela Brem,2 and Jürgen Heesemann2*

Institut für Mikrobiologie, D-BIOL, ETHZ, 8092 Zürich, Switzerland,1 Max von Pettenkofer-Institut für Hygiene und Medizinische Mikrobiologie, 80336 Munich, Germany2

Received 19 March 2003/ Accepted 27 June 2003

The Irp9 protein of Yersinia enterocolitica participates in the synthesis of salicylate, the precursor of the siderophore yersiniabactin. In Pseudomonas species, salicylate synthesis is mediated by two enzymes: isochorismate synthase and isochorismate pyruvate-lyase. Both enzymes are required for complementation of a Yersinia irp9 mutant. However, irp9 is not able to complement Escherichia coli entC for the production of enterobactin, which requires isochorismate as a precursor. These results suggest that Irp9 directly converts chorismate into salicylate.

* Corresponding author. Mailing address: Max von Pettenkofer-Institut für Hygiene und Medizinishce Mikrobiologie, Pettenkoferstr. 9a, 80336 Munich, Germany. Phone: 49 89 5160 5200. Fax: 49 89 5160 5202. E-mail: heesemann{at}m3401.mpk.med.uni-muenchen.de.

Journal of Bacteriology, September 2003, p. 5648-5653, Vol. 185, No. 18
0021-9193/03/$08.00+0     DOI: 10.1128/JB.185.18.5648-5653.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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