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Strictly Polyphosphate-Dependent Glucokinase in a Polyphosphate-Accumulating Bacterium, Microlunatus phosphovorus

Department of Molecular Biotechnology, Hiroshima University, Hiroshima 739-8530,¹ PRESTO, Japan Science and Technology Corporation, Kawaguchi, Saitama 332-0012,² Institute for Biological Resources and Functions, AIST, Ibaraki 305-8566, Japan³

Received 21 April 2003/ Accepted 23 June 2003

ATP-dependent glucokinase is suggested to have evolved from a hypothetical polyphosphate (polyP)-dependent glucokinase (polyP-GK) via a bifunctional polyP/ATP glucokinase (polyP/ATP-GK). Here we showed that polyP-GK is present in a polyP-accumulating bacterium, Microlunatus phosphovorus. The polyP-GK produced glucose-6-P_i from glucose and polyP, but it could not phosphorylate glucose with ATP. The polyP-GK was most closely related to the polyP/ATP-GK of Mycobacterium tuberculosis.

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