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A Transcriptional Pause Synchronizes Translation with Transcription in the Tryptophanase Operon Leader Region

Feng Gong and Charles Yanofsky^*

Department of Biological Sciences, Stanford University, Stanford, California 94305-5020

Received 16 June 2003/ Accepted 12 August 2003

Regulation of transcription of the tryptophanase operon requires that translation of its leader peptide coding region, tnaC, be coupled with its transcription. We show in vitro that a transcription pause site exists at the end of the tnaC coding region and that translation of tnaC releases the paused transcription complex, coupling transcription with translation.

Present address: Department of Biochemistry and Biophysics, Washington State University, Pullman, WA 99164-4660.

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