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Journal of Bacteriology, November 2003, p. 6490-6492, Vol. 185, No. 21
0021-9193/03/$08.00+0     DOI: 10.1128/JB.185.21.6490-6492.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Host Range of Chlamydiaphages {phi}CPAR39 and Chp3

J. S. Everson,1 S. A. Garner,1 P. R. Lambden,1 B. A Fane,2 and I. N. Clarke1*

Molecular Microbiology and Infection, University Medical School, Southampton General Hospital, Southampton, SO16 6YD, United Kingdom,1 Department of Veterinary Science and Microbiology, The University of Arizona, Tucson, Arizona 85721-00902

Received 19 June 2003/ Accepted 3 August 2003

The host range of {phi}CPAR39 is limited to four Chlamydophila species: C. abortus, C. caviae, C. pecorum, and C. pneumoniae. Chp3 (a newly discovered bacteriophage isolated from C. pecorum) shares three of these hosts (C. abortus, C. caviae, and C. pecorum) but can additionally infect Chlamydophila felis. The ability to support replication was directly correlated with the binding properties of the respective bacteriophages with their host species. Binding studies also show that {phi}CPAR39 and Chp3 use different host receptors to infect the same host cells: cell binding is sensitive to proteinase K treatment, confirming that the chlamydiaphage receptors are proteinaceous in nature.

* Corresponding author. Mailing address: Mailpoint 814, South Block, Southampton General Hospital, Southampton, SO16 6YD, United Kingdom. Phone: 44 2380 796975. Fax: 44 2380 796992. E-mail: inc{at}soton.ac.uk.

Journal of Bacteriology, November 2003, p. 6490-6492, Vol. 185, No. 21
0021-9193/03/$08.00+0     DOI: 10.1128/JB.185.21.6490-6492.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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