Previous Article | Next Article 
Journal of Bacteriology, November 2003, p. 6702-6706, Vol. 185, No. 22
0021-9193/03/$08.00+0 DOI: 10.1128/JB.185.22.6702-6706.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.
Starvation Survival Response of Mycobacterium tuberculosis
Tanya Parish*
Department of Medical Microbiology, Barts and the London, Queen Mary's School of Medicine and Dentistry, London E1 2AD, United Kingdom
Received 23 June 2003/
Accepted 26 August 2003
The ability of Mycobacterium tuberculosis auxotrophs to survive long-term starvation was measured. Tryptophan and histidine auxotrophs did not survive single-amino-acid starvation, whereas a proline auxotroph did. All three auxotrophs survived complete starvation. THP-1 cells were also able to restrict the growth of the tryptophan and histidine auxotrophs.
* Mailing address: Department of Medical Microbiology, Barts and the London, Queen Mary's School of Medicine and Dentistry, Turner St., London E1 2AD, United Kingdom. Phone: 44 (0)20 7377 7000, ext. 2961. Fax: 44 (0)20 7377 7259. E-mail: t.parish{at}qmul.ac.uk.
Journal of Bacteriology, November 2003, p. 6702-6706, Vol. 185, No. 22
0021-9193/03/$08.00+0 DOI: 10.1128/JB.185.22.6702-6706.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.
This article has been cited by other articles:
-
Schneider, C. Z., Parish, T., Basso, L. A., Santos, D. S.
(2008). The Two Chorismate Mutases from both Mycobacterium tuberculosis and Mycobacterium smegmatis: Biochemical Analysis and Limited Regulation of Promoter Activity by Aromatic Amino Acids. J. Bacteriol.
190: 122-134
[Abstract]
[Full Text]
-
Geiman, D. E., Raghunand, T. R., Agarwal, N., Bishai, W. R.
(2006). Differential Gene Expression in Response to Exposure to Antimycobacterial Agents and Other Stress Conditions among Seven Mycobacterium tuberculosis whiB-Like Genes.. Antimicrob. Agents Chemother.
50: 2836-2841
[Abstract]
[Full Text]
-
Marino, M., Deuss, M., Svergun, D. I., Konarev, P. V., Sterner, R., Mayans, O.
(2006). Structural and Mutational Analysis of Substrate Complexation by Anthranilate Phosphoribosyltransferase from Sulfolobus solfataricus. J. Biol. Chem.
281: 21410-21421
[Abstract]
[Full Text]
-
Carroll, P., Muttucumaru, D. G. N., Parish, T.
(2005). Use of a Tetracycline-Inducible System for Conditional Expression in Mycobacterium tuberculosis and Mycobacterium smegmatis. Appl. Environ. Microbiol.
71: 3077-3084
[Abstract]
[Full Text]
-
Rhee, K. Y., Erdjument-Bromage, H., Tempst, P., Nathan, C. F.
(2005). S-nitroso proteome of Mycobacterium tuberculosis: Enzymes of intermediary metabolism and antioxidant defense. Proc. Natl. Acad. Sci. USA
102: 467-472
[Abstract]
[Full Text]
Copyright © 2003 by the American Society for Microbiology. All rights reserved.