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Journal of Bacteriology, November 2003, p. 6702-6706, Vol. 185, No. 22
0021-9193/03/$08.00+0     DOI: 10.1128/JB.185.22.6702-6706.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Starvation Survival Response of Mycobacterium tuberculosis

Department of Medical Microbiology, Barts and the London, Queen Mary's School of Medicine and Dentistry, London E1 2AD, United Kingdom

Received 23 June 2003/ Accepted 26 August 2003

The ability of Mycobacterium tuberculosis auxotrophs to survive long-term starvation was measured. Tryptophan and histidine auxotrophs did not survive single-amino-acid starvation, whereas a proline auxotroph did. All three auxotrophs survived complete starvation. THP-1 cells were also able to restrict the growth of the tryptophan and histidine auxotrophs.

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