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Journal of Bacteriology, November 2003, p. 6702-6706, Vol. 185, No. 22
0021-9193/03/$08.00+0     DOI: 10.1128/JB.185.22.6702-6706.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Starvation Survival Response of Mycobacterium tuberculosis

Tanya Parish*

Department of Medical Microbiology, Barts and the London, Queen Mary's School of Medicine and Dentistry, London E1 2AD, United Kingdom

Received 23 June 2003/ Accepted 26 August 2003

The ability of Mycobacterium tuberculosis auxotrophs to survive long-term starvation was measured. Tryptophan and histidine auxotrophs did not survive single-amino-acid starvation, whereas a proline auxotroph did. All three auxotrophs survived complete starvation. THP-1 cells were also able to restrict the growth of the tryptophan and histidine auxotrophs.

* Mailing address: Department of Medical Microbiology, Barts and the London, Queen Mary's School of Medicine and Dentistry, Turner St., London E1 2AD, United Kingdom. Phone: 44 (0)20 7377 7000, ext. 2961. Fax: 44 (0)20 7377 7259. E-mail: t.parish{at}qmul.ac.uk.

Journal of Bacteriology, November 2003, p. 6702-6706, Vol. 185, No. 22
0021-9193/03/$08.00+0     DOI: 10.1128/JB.185.22.6702-6706.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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