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Journal of Bacteriology, November 2003, p. 6707-6711, Vol. 185, No. 22
0021-9193/03/$08.00+0     DOI: 10.1128/JB.185.22.6707-6711.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Secretion Defects That Activate the Phage Shock Response of Escherichia coli

Susan E. Jones, Louise J. Lloyd, Kum K. Tan, and Martin Buck*

Department of Biological Sciences, Imperial College London, South Kensington Campus, London SW7 2AZ, United Kingdom

Received 23 April 2003/ Accepted 20 August 2003

The phage shock protein (psp) operon of Escherichia coli is induced by membrane-damaging cues. Earlier studies linked defects in secretion across the inner membrane to induction of the psp response. Here we show that defects in yidC and sec secretion induce psp but that defects in tat and srp have no effect. We have also determined the cellular location of PspB and PspD proteins.


* Corresponding author. Mailing address: Department of Biological Sciences, Sir Alexander Fleming Building, Imperial College London, South Kensington Campus, London SW7 2AZ, United Kingdom. Phone: 44 020 7594 5442. Fax: 44 020 7594 5419. E-mail: m.buck{at}imperial.ac.uk.


Journal of Bacteriology, November 2003, p. 6707-6711, Vol. 185, No. 22
0021-9193/03/$08.00+0     DOI: 10.1128/JB.185.22.6707-6711.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.




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